| Type | Description |
|---|---|
| Definition | pyrroline-5-carboxylate reductase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:00:00 | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. | 32330411 |
| 2017-06-24 12:47:00 | PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction. | 27130255 |
| 2017-02-18 11:48:00 | It was found that silence of PYCR2 resulted in the decrease of proliferative ability and activation of AMPK/mTOR-induced autophagy of A375 cells. PYCR2 silencing also activated AMPK/mTOR pathway in another melanoma cell line, CHL-1. | 26634742 |
| 2016-12-17 11:37:00 | Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. | 26733354 |
| 2015-08-01 10:58:00 | Hypomyelination and the absence of lax caused by previously reported mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable role for PYCR2 in the human CNS during development. | 25865492 |
| Type | IDs |
|---|---|
| Synonymous | HLD10, P5CR2 |
| Gene |
UniProtKB-ID:
P5CR2_HUMAN,
A0A087WTV6_HUMAN,
A0A0S2Z5U6_HUMAN
UniprotKB:
Q96C36,
A0A087WTV6,
A0A0S2Z5U6
UniParc:
UPI000299104C,
UPI000006F2BB
EMBL:
CH471098,
AF087859,
BC020553,
AK291913,
KU178615,
AL117348,
BC014868
Ensembl:
ENSG00000143811
KO:
hsa:29920
|
| Nucleutide sequences |
EMBL-CDS:
AAH14868.1,
AAH20553.1,
EAW69762.1,
BAF84602.1,
AAP97169.1,
ALQ34073.1
Ensembl_TRS:
ENST00000343818,
ENST00000612039
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000342502,
ENSP00000478165
RefSeq:
NP_001258610.1,
NP_037460.2
|
| Others |
UniRef100:
UniRef100_Q96C36,
UniRef100_A0A087WTV6
UniRef90:
UniRef90_Q96C36,
UniRef90_A0A087WTV6
UniRef50:
UniRef50_P32322,
UniRef50_A0A087WTV6
UniGene:
Hs.654718
CCDS:
CCDS31043.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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