| Type | Description |
|---|---|
| Definition | hook microtubule tethering protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:11:00 | Coding Variants in HOOK2 and GTPBP3 May Contribute to Risk of Primary Angle Closure Glaucoma | 32397755 |
| 2018-06-02 11:48:00 | We first demonstrate that Hook2 is essential for the polarized Golgi re-orientation towards the migration front. Depletion of Hook2 results in a decrease of PAR6alpha at the centrosome during cell migration, while overexpression of Hook2 in cells induced the formation of aggresomes with the recruitment of PAR6alpha, and PAR3 | 27624926 |
| 2018-01-06 11:57:00 | differential methylation profile of the HOOK2 gene in individuals with T2D and obesity might be related to the attendant T2D, but further studies are required to identify the potential role of HOOK2 gene in T2D disease | 29228058 |
| 2012-04-14 10:29:00 | Hook2 localizes at the Golgi apparatus and centrosome/basal body, a strategic partitioning for ciliogenesis. Hook2 interacts with PCM1. | 21998199 |
| 2010-02-15 11:40:00 | Results identify Hook2, a linker protein that is essential for regulation of the microtubule network at the centrosome, as a binding partner of CENP-F. | 19793914 |
| Type | IDs |
|---|---|
| Synonymous | HK2 |
| Gene |
UniProtKB-ID:
HOOK2_HUMAN
UniprotKB:
Q96ED9
UniParc:
UPI00003D0BC0,
UPI000013D579
EMBL:
AF044924,
AC018761,
BC012443
Ensembl:
ENSG00000095066
KO:
hsa:29911
|
| Nucleutide sequences |
EMBL-CDS:
AAC09299.1,
AAH12443.1
Ensembl_TRS:
ENST00000264827,
ENST00000397668
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380785,
ENSP00000264827
RefSeq:
NP_001093646.1,
NP_037444.2
|
| Others |
UniRef100:
UniRef100_Q96ED9
UniRef90:
UniRef90_Q96ED9
UniRef50:
UniRef50_Q96ED9
UniGene:
Hs.30792
CCDS:
CCDS42507.1,
CCDS42508.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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