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29876 Clic4

29876

Clic4

chloride intracellular channel 4 (mitochondrial)

protein-coding

Mus musculus

基因描述

Type Description
Definition chloride intracellular channel 4 (mitochondrial)

研究结论

Date Results Publications
2018-07-07 11:56:00 Results demonstrate that down-regulating CLIC4 inhibit the proliferation and promotes the apoptosis of mouse liver cancer Hca-F cell. 28636115
2017-12-09 11:44:00 Results indicate CLICs (CLIC1, CLIC4 and CLIC5)-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation. 28779175
2017-08-12 10:16:00 Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 inflammasomes; in LPS macrophage activation, Clic1 and Clic4 are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 = NLR family pyrin domain containing 3) 28576828
2017-07-29 11:27:00 study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta and CLIC4, is a dominant inhibitor of Smad7 and enhances TGF-beta signaling 27536941
2017-07-08 10:11:00 The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture. 27582103

名称对应

Type IDs
Synonymous D0Jmb3, TU-74, mc3s5, mtCLIC
Gene
UniProtKB-ID: CLIC4_MOUSE, Q543N5_MOUSE
UniprotKB: Q9QYB1, Q543N5
UniParc: UPI0000004099
EMBL: AK172516, AK159402, AK152273, AK172026, AK153432, AK169376, AK171243, AK170942, AF102578, AK150993, BC052890, AK169834, AK160856, AK166794, AK031211, AK155826, AK049191, BC046384, AK172660, CT010279
Ensembl: ENSMUSG00000037242
KO: mmu:29876
Nucleutide sequences
EMBL-CDS: AAF19055.1, BAC27301.1, AAH52890.1, AAH46384.1, BAE31089.1, BAE39023.1, BAE33450.1, BAC33601.1, BAE42784.1, BAE43120.1, BAE35054.1, BAE41124.1, BAE42336.1, BAE30017.1, BAE42130.1, CAJ18487.1, BAE41399.1, BAE36049.1, BAE31990.1, BAE43045.1
Ensembl_TRS: ENSMUST00000037099
Protein sequencees
Ensembl_PRO: ENSMUSP00000041453
RefSeq: NP_038913.1
Others
UniRef100: UniRef100_Q9QYB1
UniRef90: UniRef90_Q9QYB1
UniRef50: UniRef50_Q9QYB1
UniGene: Mm.257765
CCDS: CCDS18783.1

全选

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