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29869 Ulk2

29869

Ulk2

unc-51 like kinase 2

protein-coding

Mus musculus

基因描述

Type Description
Definition unc-51 like kinase 2

研究结论

Date Results Publications
2020-06-06 10:08:00 that skeletal muscle ULK2 has a unique role in basal selective protein degradation by stimulating the recognition and proteolytic sequestration of insoluble ubiquitinated protein aggregates 31361156
2019-10-19 10:58:00 we demonstrate that disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions; this myopathy is similar to that caused by VCP/p97 mutations, the most common cause of familial inclusion body myopathy (IBM) 30979586
2019-10-05 11:13:00 ULK1 and ULK2 regulate axon guidance during mammalian brain development via a noncanonical (i.e., autophagy-independent) pathway. 29099309
2019-03-16 10:11:00 Here we show that Ulk2 heterozygous (Ulk2+/-) mice have upregulated expression of sequestosome-1/p62, an autophagy-associated stress response protein, predominantly in pyramidal neurons of the prefrontal cortex (PFC), and exhibit behavioral deficits associated with the PFC functions, including attenuated sensorimotor gating and impaired cognition 29893844
2017-08-19 12:04:00 Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis. 27203176

名称对应

Type IDs
Synonymous A830085I22Rik, AU015340, Unc51.2, mKIAA0623
Gene
UniProtKB-ID: ULK2_MOUSE, Q3UG39_MOUSE
UniprotKB: Q9QY01, Q3UG39
UniParc: UPI00005AC763, UPI000000BAC9
EMBL: AK146620, AB019577, AK122331, BC046778, AF145922, AK148142, BC053029
Ensembl: ENSMUSG00000004798
KO: mmu:29869
Nucleutide sequences
EMBL-CDS: BAC65613.2, BAE27309.1, AAF18325.1, AAH46778.1, AAH53029.1, BAA77341.1, BAE28370.1
Ensembl_TRS: ENSMUST00000004920
Protein sequencees
Ensembl_PRO: ENSMUSP00000004920
RefSeq: XP_036012647.1, XP_030101926.1, NP_038909.3, XP_006533572.1, XP_036012645.1, XP_006533571.1, XP_036012646.1, XP_036012644.1
Others
UniRef100: UniRef100_Q3UG39, UniRef100_Q9QY01
UniRef90: UniRef90_Q9QY01
UniRef50: UniRef50_Q9QY01
UniGene: Mm.162025
CCDS: CCDS24820.1

全选

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