| Type | Description |
|---|---|
| Definition | guanylate cyclase 2C |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 12:11:00 | Study reveals two discrete neuronal circuits expressing GUCY2C originating in the ventral premammillary nucleus in the hypothalamus and in the ventral tegmental area and substantia nigra in midbrain, which separately project to other sites throughout the brain. | 31485718 |
| 2019-04-20 12:11:00 | The results support a role of guanylate cyclase C signaling and disturbed electrolyte homeostasis in development of IBD. Furthermore, downregulation of metallothioneins in the ileal mucosa of familial GUCY2C diarrhea syndrome patients may contribute to inflammatory bowel disease development, possibly alongside effects from NOD2 risk variants. | 30353760 |
| 2019-03-30 10:19:00 | Human GUCY2C-targeted murine CAR-T cells promoted antigen-dependent T-cell activation quantified by activation marker upregulation, cytokine production, and killing of GUCY2C-expressing, but not GUCY2C-deficient, cancer cells in vitro GUCY2C CAR-T cells provided long-term protection against lung metastases of murine colorectal cancer cells engineered to express human GUCY2C in a syngeneic mouse model. | 29615399 |
| 2018-06-09 11:20:00 | High Expressions of guanylyl cyclase C is associated with rectal cancer. | 28418917 |
| 2018-06-02 11:43:00 | The findings support that the activating mutation in GUCY2C creates an intestinal environment with a major influence on the microbiota, which could contribute to the increased susceptibility to inflammatory bowel disease in patients with Familial GUCY2C diarrhea syndrome. | 28902124 |
| Type | IDs |
|---|---|
| Synonymous | DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR |
| Gene |
UniProtKB-ID:
GUC2C_HUMAN
UniprotKB:
P25092
UniParc:
UPI000013D135
EMBL:
BC136545,
BC136544,
S57551,
U20230,
AC007545,
M73489,
CH471094,
AC010168
Ensembl:
ENSG00000070019
KO:
hsa:2984
|
| Nucleutide sequences |
EMBL-CDS:
AAB19934.2,
AAI36546.1,
AAC50381.1,
EAW96324.1,
AAA36655.1,
AAI36545.1
Ensembl_TRS:
ENST00000261170
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261170
RefSeq:
NP_004954.2,
XP_011518933.1
|
| Others |
UniRef100:
UniRef100_P25092
UniRef90:
UniRef90_P25092
UniRef50:
UniRef50_P25092
UniGene:
Hs.524278
CCDS:
CCDS8664.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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