| Type | Description |
|---|---|
| Definition | guanylate cyclase activator 2B |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 13:57:00 | This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. Sexual dimorphism exists in circulating pro-uroguanylin levels with respect to Body Mass Index. | 30266914 |
| 2019-06-01 10:16:00 | The intestinal expression of uroguanylin, a key satiety hormone, appears to be diminished in female pediatric patients in the setting of obesity. | 28847213 |
| 2019-04-20 11:49:00 | In female adolescents without obesity, levels of pro-uroguanylin are higher than in those with obesity. Pro-uroguanylin secretion patterns differ from other circulating gastrointestinal peptides. In female adolescents with obesity, inflammation correlates with decreased pro-uroguanylin levels. | 29112082 |
| 2018-12-29 10:19:00 | Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. | 29289697 |
| 2018-02-24 10:14:00 | Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity. | 27108812 |
| Type | IDs |
|---|---|
| Synonymous | GCAP-II, UGN |
| Gene |
UniProtKB-ID:
GUC2B_HUMAN
UniprotKB:
Q16661
UniParc:
UPI000002E39E
EMBL:
U34279,
Z70295,
BC093779,
U55058,
Z50753,
BC069301,
BC093781
Ensembl:
ENSG00000044012
KO:
hsa:2981
|
| Nucleutide sequences |
EMBL-CDS:
AAC51729.1,
CAA90629.1,
AAC50416.1,
AAH93779.1,
AAH69301.1,
CAA94311.1,
AAH93781.1
Ensembl_TRS:
ENST00000372581
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361662
RefSeq:
NP_009033.1
|
| Others |
UniRef100:
UniRef100_Q16661
UniRef90:
UniRef90_Q16661
UniRef50:
UniRef50_Q16661
UniGene:
Hs.32966
CCDS:
CCDS464.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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