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2979 GUCA1B

2979

GUCA1B

guanylate cyclase activator 1B

protein-coding

Homo sapiens

基因描述

Type Description
Definition guanylate cyclase activator 1B

研究结论

Date Results Publications
2018-11-10 11:05:00 GCAP1 and GCAP2 bound to different regions on the target guanylate cyclase type 1 with submicromolar affinity (apparent KD-values of 663 +/- 121 nM and 231 +/- 63 nM for Ca(2+)-free GCAP1 and GCAP2, respectively). 28361875
2015-11-07 10:04:00 Dimerization domain of RETGC1 is an essential part of GCAP1 and GCAP2 binding interface. 26100624
2015-05-30 12:14:00 The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1. 25616661
2011-11-12 10:56:00 The absence of clearly pathogenic mutations in the selected patient group suggests that the GUCA1B gene is a minor cause for retinal degenerations in Europeans or North-Americans. 21405999
2010-01-21 00:00:00 Mutation in the GCAP 2 gene can cause one form of autosomal dominant retinal dystrophy, with variable phenotypic expression and incomplete penetrance. 15452722

名称对应

Type IDs
Synonymous GCAP 2, GCAP2, GUCA2, RP48
Gene
UniProtKB-ID: GUC1B_HUMAN, Q7Z3V9_HUMAN
UniprotKB: Q9UMX6, Q7Z3V9
UniParc: UPI00001A9960, UPI000013C92C
EMBL: AF173229, AF173227, AF173228, BX537393, AL096814
Ensembl: ENSG00000112599
KO: hsa:2979
Nucleutide sequences
EMBL-CDS: AAD47279.1, CAD97635.1
Ensembl_TRS: ENST00000230361
Protein sequencees
Ensembl_PRO: ENSP00000230361
RefSeq: NP_002089.4
Others
UniRef100: UniRef100_Q7Z3V9, UniRef100_Q9UMX6
UniRef90: UniRef90_Q9UMX6
UniRef50: UniRef50_Q9UMX6
UniGene: Hs.446529
CCDS: CCDS4865.1

全选

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研究热度

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