| Type | Description |
|---|---|
| Definition | solute carrier family 16 member 7 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 11:19:00 | Monocarboxylate transporter-2-knockout, which blocked the lactate shuttle in neurons, showed a remarkable decrease in the length of axons and dendrites. We further demonstrated that Akt activity was decreased while glycogen synthase kinase 3beta (GSK3beta) activity was increased after astrocytic glycogen phosphorylase blockade. Additionally, GSK3betaSer9 mutation reversed neurite growth failure caused by DAB and isofag... | 30143583 |
| 2017-09-09 14:08:00 | data not only demonstrate that glucose-derived lactate is locally produced following neuronal activation but also suggest that its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex | 28388627 |
| 2016-08-13 12:18:00 | MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation. | 26831515 |
| 2015-09-26 15:02:00 | resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism. | 25827488 |
| 2015-01-31 11:37:00 | MCT2 increased in the hippocampus immediately after exercise and in the cortex and hypothalamus 5-24 h postexercise. | 24610532 |
| Type | IDs |
|---|---|
| Synonymous | Mct2 |
| Gene |
UniProtKB-ID:
Q66HS9_RAT
UniprotKB:
Q66HS9
UniParc:
UPI000019BA1F
EMBL:
BC081701,
CH473950,
AABR07057379,
AABR07057378
Ensembl:
ENSRNOG00000007839
KO:
rno:29735
|
| Nucleutide sequences |
EMBL-CDS:
AAH81701.1,
EDM16524.1,
EDM16525.1
Gene_ORFName:
rCG_59598
Ensembl_TRS:
ENSRNOT00000058036,
ENSRNOT00000077670,
ENSRNOT00000078014
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000075465,
ENSRNOP00000054845,
ENSRNOP00000073329
RefSeq:
XP_006241498.1,
XP_006241495.1,
XP_006241494.1,
NP_058998.2,
XP_006241497.1,
XP_006241499.1,
XP_006241496.1
|
| Others |
UniRef100:
UniRef100_Q66HS9
UniRef90:
UniRef90_Q63344
UniRef50:
UniRef50_O70451
UniGene:
Rn.10524,
Rn.217495
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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