| Type | Description |
|---|---|
| Definition | BRF1 RNA polymerase III transcription initiation factor subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:49:00 | The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells. | 32115405 |
| 2020-11-28 13:12:00 | BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. | 31740786 |
| 2020-05-02 12:23:00 | Runx2 mediates the deregulation of Brf1 and Pol III genes and its abnormal expression predicts the worse prognosis of breast cancer. | 32198086 |
| 2020-04-25 12:08:00 | Recent studies have demonstrated that Brf1 is overexpressed in most ER+ (estrogen receptor positive) cases of breast cancer and the change in cellular levels of Brf1 reflects the therapeutic efficacy and prognosis of this disease. It suggests that Brf1 may be a potential diagnosis biomarker and a therapeutic target of alcohol-associated breast cancer. | 31781337 |
| 2019-12-21 10:50:00 | A derivative of TIS11b called R9-ZnC(S334D), by combining N-terminal domain deletion, serine-to-aspartate substitution at position 334 to enhance the function of the protein and fusion to the cell-penetrating peptide polyarginine R9. R9-ZnC(S334D) not only blunted secretion of vascular endothelial growth factor (VEGF) but also inhibited proliferation, migration, invasion, and anchorage-independent growth of breast cancer. | 30914800 |
| Type | IDs |
|---|---|
| Synonymous | BRF, BRF-1, CFDS, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF |
| Gene |
UniProtKB-ID:
TF3B_HUMAN,
A0A024R6P8_HUMAN,
V9HVY2_HUMAN
UniprotKB:
Q92994,
A0A024R6P8,
V9HVY2
UniParc:
UPI0000E018AC,
UPI0000EE3513,
UPI000206520D,
UPI000002B529,
UPI000002B528,
UPI000002B52A,
UPI0000136C55,
UPI000006FD40,
UPI00001FDD19
EMBL:
U28838,
AK295579,
AL512355,
BC086856,
EU668327,
AJ297406,
AJ297407,
AK294899,
BC016743,
AJ297408,
CH471061,
BC071637,
U75276,
AK096471,
BC103859
Ensembl:
ENSG00000185024
KO:
hsa:2972
|
| Nucleutide sequences |
EMBL-CDS:
BAG53298.1,
AAH86856.1,
AAI03860.1,
AAH71637.1,
EAW81908.1,
EAW81911.1,
BAH11919.1,
CAC04512.1,
AAB38876.1,
AAC50170.1,
CAC04513.1,
CAC04514.1,
AAH16743.1,
BAG58477.1,
EAW81909.1,
EAW81907.1,
EAW81912.1,
ACF94480.1
Gene_ORFName:
hCG_19130
Ensembl_TRS:
ENST00000327359,
ENST00000392557,
ENST00000548421,
ENST00000379937,
ENST00000446501,
ENST00000547530,
ENST00000440513
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000446707,
ENSP00000389859,
ENSP00000369269,
ENSP00000329029,
ENSP00000388877,
ENSP00000448387,
ENSP00000376340
RefSeq:
NP_001229718.1,
XP_005267620.1,
NP_001510.2,
NP_001229715.1,
NP_001229719.1,
XP_005267618.1,
NP_663718.1,
XP_011534975.1,
XP_024305321.1,
NP_001229716.1,
NP_001229717.1,
XP_011534974.1
|
| Others |
UniRef100:
UniRef100_Q92994,
UniRef100_V9HVY2
UniRef90:
UniRef90_Q92994,
UniRef90_Q92994-4
UniRef50:
UniRef50_Q92994,
UniRef50_Q92994-4
UniGene:
Hs.424484
CCDS:
CCDS42001.1,
CCDS10001.1,
CCDS55950.1,
CCDS55951.1,
CCDS55949.1,
CCDS55952.1,
CCDS55953.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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