| Type | Description |
|---|---|
| Definition | sodium voltage-gated channel alpha subunit 8 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-22 10:52:00 | Study found that knockdown of either NaV1.6 or NaVbeta4 reduced pain behaviors and sensory neuron hyperexcitability in the chronic compression dorsal rook ganglia model of low back pain. | 30699332 |
| 2018-06-09 11:46:00 | To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct models of temporal lobe epilepsy including a post-status epilepticus model induced by kainic acid intrahippocampal injection and a kindling model evoked by pentylenetetrazole. | 27905510 |
| 2018-05-05 12:03:00 | Data strongly suggest that voltage-gated sodium channel subunit alpha Nav1.6 ( Nav1.6) plays an indispensable role in the peripheral pain hypersensitivity induced by BmK I. | 28655185 |
| 2017-07-15 11:54:00 | Study provides insight into the dynamics of Nav1.6 on the cell surface and raises new questions such as how somatic localization and function are linked and how localized regulation of these channels may influence overall neuronal physiology. | 27653482 |
| 2016-01-16 10:31:00 | The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development. | 25874799 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SCN8A_RAT
UniprotKB:
O88420
UniParc:
UPI00000E7E9D,
UPI00000E6F7F
EMBL:
AF049239,
AF049240
KO:
rno:29710
|
| Nucleutide sequences |
EMBL-CDS:
AAC26015.1,
AAC26014.1
|
| Protein sequencees |
RefSeq:
NP_062139.2
|
| Others |
UniRef100:
UniRef100_O88420
UniRef90:
UniRef90_Q9WTU3
UniRef50:
UniRef50_Q9UQD0
UniGene:
Rn.91216
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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