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29628 Gria3

29628

Gria3

glutamate ionotropic receptor AMPA type subunit 3

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition glutamate ionotropic receptor AMPA type subunit 3

研究结论

Date Results Publications
2019-07-20 10:13:00 Study shows that oxygen and glucose deprivation (OGD) causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AMPARs, and that PICK1 is required for both OGD-induced GluA2 endocytosis and lysosomal sorting. GluA1-containing AMPARs resist OGD-induced endocytosis and PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical neurons. 28951554
2017-10-07 12:22:00 results lead to a model of cooperative activation of mGluRs that provides a framework for understanding how class C GPCRs couple extracellular binding to dimer reorganization and G protein activation. 27641494
2016-03-12 11:26:00 This study showed that GluA3 is uniformly distributed along the synapse, and seldom extends beyond its lateral border in hippocamoys. 25524891
2013-11-16 10:07:00 The results of this study support the local translation of GluA1-4 mRNAs in dendrites of hippocampal pyramidal cells and CA1 interneurons but not in granule cells of the dentate gyrus. 23296627
2013-10-19 12:18:00 A decrease in GluA1 and increases in GluA3 subunit and expression at the end of the third postnatal week provide a molecular explanation for the increase in AMPAR response duration and reduced efficacy of AMPAR modulators with increasing age. 23884930

名称对应

Type IDs
Synonymous GLUR3, GluA3, GluR-3, GluR-C, GluR-K3
Gene
UniProtKB-ID: GRIA3_RAT, G3V8Y9_RAT, G3V6Z5_RAT
UniprotKB: P19492, G3V8Y9, G3V6Z5
UniParc: UPI0000033423, UPI0000251119, UPI000019BA1D, UPI000002AA92
EMBL: X54656, AABR07041368, AABR07041369, M85036, M38062, AABR07041370, AABR07041371, AABR07041373, M36420, AABR07041375, CH473991, AABR07041374, AABR07041372
Ensembl: ENSRNOG00000007682
KO: rno:29628
Nucleutide sequences
EMBL-CDS: AAA63480.1, CAA38466.1, AAA41241.2, AAA41245.1, EDM10877.1, EDM10878.1, EDM10879.1
Gene_ORFName: rCG_53210, rCG_53210
Ensembl_TRS: ENSRNOT00000029031, ENSRNOT00000010367
Protein sequencees
Ensembl_PRO: ENSRNOP00000031170, ENSRNOP00000010367
RefSeq: XP_006257561.1, XP_006257563.1, XP_017457440.1, NP_001106213.1, XP_006257560.1, XP_017457439.1, NP_116785.2, XP_006257558.1
Others
UniRef100: UniRef100_G3V8Y9, UniRef100_G3V6Z5, UniRef100_P19492
UniRef90: UniRef90_P19492-2, UniRef90_P19492
UniRef50: UniRef50_P19492-2, UniRef50_P19492
UniGene: Rn.74049

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