| Type | Description |
|---|---|
| Definition | sodium voltage-gated channel alpha subunit 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:10:00 | Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Slack) potassium channels, demonstrating macrocomplexing with NaV1.8 channels. NaV1.8 expression decreased after Magi-1 knockdown in vivo. | 30860870 |
| 2018-06-02 10:26:00 | Treatment of AOAA markedly suppressed expression of NaV1.7 and NaV1.8 in DRGs of lumbar disc herniation (LDH) rats. These data suggest that targeting the CBS-H2S signaling at the DRG level might represent a novel therapeutic strategy for chronic pain relief in patients with LDH. | 27905525 |
| 2018-01-13 11:48:00 | Study found that trigeminal ganglion in rats subjected to an infraorbital nerve-chronic constriction injury showed upregulation of Nav1.3 and downregulation of Nav1.7, Nav1.8, and Nav1.9 messenger RNA and protein levels. Findings suggest that voltage-gated sodium channels may participate in the regulation of trigeminal neuralgia. | 27327156 |
| 2017-03-04 11:13:00 | This study demonstrated the modulation of Nav1.8 by LPA in DRG neurons, and that this probably underlies the peripheral mechanism by which bone cancer pain is induced. | 27631681 |
| 2016-11-05 11:36:00 | investigated whether the aberrant expression of Nav1.8 in dorsal root ganglia contributes to generation of pain induced by scorpion stings | 26764239 |
| Type | IDs |
|---|---|
| Synonymous | Na(V)1.8, Nav1.8, PN3 |
| Gene |
UniProtKB-ID:
SCNAA_RAT
UniprotKB:
Q62968
UniParc:
UPI0000498114,
UPI0000042434
EMBL:
X92184,
U53833,
AJ623271
Ensembl:
ENSRNOG00000032473
KO:
rno:29571
|
| Nucleutide sequences |
EMBL-CDS:
AAC52619.1,
CAA63095.1,
CAF25041.1
Ensembl_TRS:
ENSRNOT00000046864
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000047944
RefSeq:
NP_058943.2,
XP_017450992.1,
XP_017450993.1,
XP_017450994.1
|
| Others |
UniRef100:
UniRef100_Q62968
UniRef90:
UniRef90_Q62968
UniRef50:
UniRef50_Q9Y5Y9
UniGene:
Rn.10246
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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