| Type | Description |
|---|---|
| Definition | glutathione S-transferase zeta 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:25:00 | GSTZ1-1 downregulates Wnt/beta-catenin signalling in hepatocellular carcinoma cells. | 31782257 |
| 2020-07-11 12:30:00 | First clinical trial of dichloroacetate (DCA) in multiple myeloma patients revealed that GSTZ1 genotypes are correlated with drug concentrations, tolerability, and disease outcomes. Promoter GSTZ1 polymorphisms may be important determinants of DCA concentrations and neuropathy during chronic treatment. | 31624634 |
| 2020-03-28 12:07:00 | Study shows that GSTZ1 is markedly downregulated in hepatocellular carcinoma (HCC) thus predicting a poor prognosis. GSTZ1 deficiency induces oxidative stress, thus activating the KEAP1/NRF2 signaling pathway, which promotes HCC progression. | 31666108 |
| 2019-12-28 11:46:00 | Results suggested that GSTZ1-1 is downregulated in hepatocellular carcinoma (HCC) and may serve as a prognostic marker. These data indicate an alternative oncogenic action of succinylacetone through activation of the NRF2/IGF1R axis by alkylation of KEAP1. | 31267557 |
| 2018-11-17 10:22:00 | Some properties of cytosolic and mitochondrial GSTZ1 differed. | 29853471 |
| Type | IDs |
|---|---|
| Synonymous | GSTZ1-1, MAAI, MAAID, MAI |
| Gene |
UniProtKB-ID:
MAAI_HUMAN,
A0A0A0MR33_HUMAN,
A0A0C4DFM0_HUMAN
UniprotKB:
O43708,
A0A0A0MR33,
A0A0C4DFM0
UniParc:
UPI000013C6F0,
UPI000015FD29,
UPI0001BBE418,
UPI000013FA10,
UPI00033362B5
EMBL:
AF095582,
AF098313,
AF053544,
AF098317,
AF098314,
AF053542,
AF098315,
AK315154,
AF053543,
CH471061,
AJ001838,
AF053545,
AF098318,
AF098311,
BC001453,
AF098316,
CR456987,
AY316305,
AC007954,
U86529,
AF053541,
AF053539,
AF053540,
AF098312
Ensembl:
ENSG00000100577
KO:
hsa:2954
|
| Nucleutide sequences |
EMBL-CDS:
AAD43007.1,
BAG37600.1,
EAW81278.1,
CAG33268.1,
AAH01453.1,
EAW81279.1,
AAF62559.1,
AAP69526.1,
AAB96392.1,
AAC33591.1,
CAA05045.1,
EAW81280.1
Gene_ORFName:
hCG_22265
Ensembl_TRS:
ENST00000393734,
ENST00000361389,
ENST00000557639,
ENST00000349555,
ENST00000216465
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377335,
ENSP00000451927,
ENSP00000354959,
ENSP00000314404,
ENSP00000216465
RefSeq:
XP_024305319.1,
NP_001299589.1,
NP_665878.2,
NP_001350632.1,
XP_011534973.1,
XP_024305318.1,
XP_024305317.1,
NP_665877.1,
XP_024305320.1,
XP_011534972.1
|
| Others |
UniRef100:
UniRef100_A0A0A0MR33,
UniRef100_O43708,
UniRef100_A0A0C4DFM0
UniRef90:
UniRef90_G3QTP9,
UniRef90_O43708
UniRef50:
UniRef50_O43708,
UniRef50_G3QTP9
UniGene:
Hs.655292
CCDS:
CCDS9859.1,
CCDS9860.1,
CCDS9858.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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