| Type | Description |
|---|---|
| Definition | solute carrier family 22 member 6 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-06 11:23:00 | Study results indicate that Oat1 and Oat3 at the blood-arachnoid barrier provide a distinct clearance pathway of organic anion drugs from cerebrospinal fluid independently of choroid plexus. | 29436232 |
| 2018-07-14 10:43:00 | These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4 | 28534121 |
| 2018-04-28 10:48:00 | Furosemide pretreatment causes a decrease of p-aminohippurate renal elimination in rats in spite of the increased expression level of Oat1. | 27282888 |
| 2016-12-31 11:17:00 | folic acid was capable of preventing monosodium urate-induced OAT1 relocation by inhibiting the RhoA signaling pathway. | 26846716 |
| 2016-04-02 10:50:00 | In uremia, urea accounts, at least in part, for the decreased expression of Oat1 and Oat3 in proximal tubule plasma membranes. | 26065488 |
| Type | IDs |
|---|---|
| Synonymous | Oat1, Orctl1, Paht, Roat1 |
| Gene |
UniProtKB-ID:
S22A6_RAT
UniprotKB:
O35956
UniParc:
UPI00000E8778
EMBL:
BC104692,
AF008221,
AB004559
Ensembl:
ENSRNOG00000018215
KO:
rno:29509
|
| Nucleutide sequences |
EMBL-CDS:
AAI04693.1,
AAC18772.1,
BAA22086.1
Ensembl_TRS:
ENSRNOT00000024757
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000024756
RefSeq:
XP_006231040.1,
NP_058920.1
|
| Others |
UniRef100:
UniRef100_O35956
UniRef90:
UniRef90_O35956
UniRef50:
UniRef50_Q4U2R8
UniGene:
Rn.87849
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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