| Type | Description |
|---|---|
| Definition | beta-secretase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 10:40:00 | that NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis | 31014193 |
| 2018-12-22 11:21:00 | Study utilizing glutamate excitotoxicity model in rat cortical primary cell cultures suggests for the first time a more direct action of BACE1 on the hyperphosphorylation state of tau (implemented in Alzheimer's disease pathogenesis) that is mediated through cPLA2 and desaturases SCD1 and FADS6 modulation during glutamate excitotoxicity. | 30251689 |
| 2018-12-01 11:08:00 | Beta-site APP cleaving enzyme 1 knockout (Bace1-/-) mice and rats differed in body weight, spontaneous locomotor activity, and prepulse inhibition of startle. | 28281673 |
| 2017-11-11 10:34:00 | miR-9 plays an important role in regulating the process of dementia induced by occlusion of the bilateral common carotid artery in rats by increasing BACE1 expression via downregulation of CREB. | 28683457 |
| 2017-08-19 10:42:00 | beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu(11) to the Asp(1) site, resulting in much higher C99 level and C99/C89 ratio. | 28626014 |
| Type | IDs |
|---|---|
| Synonymous | Bace |
| Gene |
UniProtKB-ID:
BACE1_RAT
UniprotKB:
P56819
UniParc:
UPI0000126745
EMBL:
AF190727
Ensembl:
ENSRNOG00000016847
KO:
rno:29392
|
| Nucleutide sequences |
EMBL-CDS:
AAF04144.1
Ensembl_TRS:
ENSRNOT00000022796
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000022796
RefSeq:
NP_062077.1
|
| Others |
UniRef100:
UniRef100_P56819
UniRef90:
UniRef90_P56819
UniRef50:
UniRef50_P56817
UniGene:
Rn.207201
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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