| Type | Description |
|---|---|
| Definition | opioid receptor, kappa 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-12 12:12:00 | Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens. | 28531297 |
| 2018-04-28 10:04:00 | Using selective agonists and antagonists showed that kappa-opioid receptor stimulation normalizes endothelial ultrastructure and function under hyperlipidemic condition. Its mechanism is related to the preservation of eNOS phosphorylation through activation of the PI3K/Akt signaling pathway and downregulation of iNOS expression/activity. | 27226238 |
| 2018-01-13 13:18:00 | These data suggest that kappa opioid receptors may have increased responsiveness following social isolation, which could lead to hypodopaminergia and contribute to an increased drive to consume ethanol. | 26860203 |
| 2017-12-02 11:07:00 | Hypertension increased the expression of Kappa Opioid receptors and heterodimerization of apelin receptors and Kappa Opioid receptors, and reduced pERK1/2 in the left ventricle. | 28987634 |
| 2017-11-25 15:56:00 | triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation | 27899527 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
OPRK_RAT
UniprotKB:
P34975
UniParc:
UPI0000130D99
EMBL:
U17994,
L22536,
D16534,
U17995,
L22001,
U00442,
U17993,
D16829
Ensembl:
ENSRNOG00000007647
KO:
rno:29335
|
| Nucleutide sequences |
EMBL-CDS:
AAA18261.1,
AAA41496.1,
BAA04109.1,
AAC53249.1,
AAA41495.1,
BAA03971.1
Ensembl_TRS:
ENSRNOT00000010254
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000010255
RefSeq:
XP_017448692.1,
NP_058863.1,
NP_001305671.1
|
| Others |
UniRef100:
UniRef100_P34975
UniRef90:
UniRef90_P41145
UniRef50:
UniRef50_P35372-3
UniGene:
Rn.89571
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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