| Type | Description |
|---|---|
| Definition | tight junction protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:15:00 | Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. | 31975378 |
| 2020-07-04 11:45:00 | The HIF-1alpha positively regulates the expression of MLCK and p-MLC and negatively regulates the expression of ZO-1 in rat monolayer endothelial cells. | 31540688 |
| 2020-06-27 12:15:00 | we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. | 31506421 |
| 2020-05-02 12:58:00 | This study identified that Cd induces a reactive oxygen species -dependent endoplasmic reticulum stress-mediated signaling pathway involving caspase-3 activation that triggers ATP release by a PANX1 channel-independent mechanism, leading to structural morphologic alterations of the ZO-1 TJ component in a rat brain endothelial cell line (RBE4), a well-characterized and widely used Blood Brain Barrier model. | 31795317 |
| 2019-03-16 11:13:00 | High-glucose exposure in early reperfusion causes blood-brain barrier disruption, with MMP-2/9-mediated extracellular degradation, caveolin-1-mediated intracellular translocation and autophagy-lysosome-mediated degradation of ZO-1 protein all together involved in the process. The role of MMP-2/-9 and autophagy in the modulation of paracellular permeability was confirmed by pharmacological inhibition. | 29524637 |
| Type | IDs |
|---|---|
| Synonymous | ZO-1 |
| Gene |
UniProtKB-ID:
F1M4A0_RAT
UniprotKB:
F1M4A0
UniParc:
UPI000154F9DF
EMBL:
CH473980,
AABR07004128,
AABR07004129
Ensembl:
ENSRNOG00000011077
KO:
rno:292994
|
| Nucleutide sequences |
EMBL-CDS:
EDM08402.1
Gene_ORFName:
rCG_24681
Ensembl_TRS:
ENSRNOT00000014988
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000014988
RefSeq:
XP_006229392.1,
XP_017444423.1,
XP_017444420.1,
XP_017444425.1,
NP_001099736.1,
XP_006229395.1,
XP_017444424.1,
XP_017444421.1,
XP_017444419.1,
XP_017444422.1,
XP_006229393.1,
XP_006229394.1
|
| Others |
UniRef100:
UniRef100_F1M4A0
UniRef90:
UniRef90_P39447
UniRef50:
UniRef50_Q07157
UniGene:
Rn.101871
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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