| Type | Description |
|---|---|
| Definition | AKT1 substrate 1 |
| Date | Results | Publications |
|---|---|---|
| 2014-09-27 12:46:00 | PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR | 24583056 |
| 2014-07-26 12:45:00 | These data suggested that phosphorylation of PRAS40-Thr246 mediated abnormal lipid metabolism in kidney of diabetes and might be the potential target for treating lipogenesis of diabetic nephropathy. | 24347388 |
| 2012-08-25 10:20:00 | Taken together, these data demonstrate that IGF-1 stimulates the phosphorylation of PRAS40 at Thr246 in neuronal cells and the effect of IGF-1 is mediated, at least in part, by the PI3K/Akt signaling pathway. | 22490886 |
| 2010-09-20 12:35:00 | Data identify high glucose-induced phosphorylation and inactivation of PRAS40 as a central node for mesangial cell hypertrophy in diabetic nephropathy. | 20629086 |
| 2010-01-21 00:00:00 | overexpression of SOD1 in the Tg rats results in an increase in endogenous pPRAS40 and a decrease in motor neuron death through the PI3K/Akt pathway. | 17457363 |
| Type | IDs |
|---|---|
| Synonymous | PRAS40 |
| Gene |
UniProtKB-ID:
D3ZH75_RAT
UniprotKB:
D3ZH75
UniParc:
UPI0000180DF1
EMBL:
CH473979,
AC094894
Ensembl:
ENSRNOG00000020289
KO:
rno:292887
|
| Nucleutide sequences |
EMBL-CDS:
EDM07453.1
Gene_ORFName:
rCG_53542
Ensembl_TRS:
ENSRNOT00000027478
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000027478
RefSeq:
XP_008757557.1,
XP_006229065.1,
XP_006229066.1,
NP_001099729.2,
XP_006229067.1
|
| Others |
UniRef100:
UniRef100_D3ZH75
UniRef90:
UniRef90_D3ZH75
UniRef50:
UniRef50_D3ZH75
UniGene:
Rn.102669,
Rn.234559
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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