| Type | Description |
|---|---|
| Definition | adenylate cyclase 8 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-22 10:46:00 | Data show that the IL-1beta-dependent transdifferentiation of VSMCs is associated with the de novo expression of a new family of AC8 isoforms. These isoforms are catalytically inactive with dominant-negative effects, decreasing total cAMP production. The inhibitory effect of AC8E on adenylyl cyclases (ACs) activity is accompanied by the formation of heterodimers between AC8E and functional ACs. | 29940197 |
| 2013-01-12 10:49:00 | Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype. | 22531884 |
| 2012-10-20 11:48:00 | AC8 expression, besides being induced by the proinflammatory cytokine IL1beta, is also dependent on down-regulation of the Notch pathway occurring in an inflammatory context. | 22613711 |
| 2011-11-26 11:25:00 | Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8. | 21771783 |
| 2011-05-07 11:04:00 | cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R. | 21046358 |
| Type | IDs |
|---|---|
| Synonymous | Ac8 |
| Gene |
UniProtKB-ID:
ADCY8_RAT
UniprotKB:
P40146
UniParc:
UPI000F073056,
UPI000012887D,
UPI000F07304D,
UPI000F07304F
EMBL:
L26986
KO:
rno:29241
|
| Nucleutide sequences |
EMBL-CDS:
AAA20504.1
|
| Protein sequencees |
RefSeq:
NP_058838.1,
XP_006241766.1,
XP_006241765.1
|
| Others |
UniRef100:
UniRef100_P40146
UniRef90:
UniRef90_P40146
UniRef50:
UniRef50_P40146
UniGene:
Rn.10382
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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