| Type | Description |
|---|---|
| Definition | LDL receptor related protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:08:00 | Megalin: A Novel Endocytic Receptor for Prorenin and Renin. | 32200675 |
| 2019-09-21 10:48:00 | Renal megalin expression was found to be upregulated in early type 2 diabetic rats in a process that may involve high glucose and insulin in a PI3K/Akt-dependent manner. | 29949391 |
| 2019-05-04 10:15:00 | Mild oxidative stress increases renal megalin expression through the phosphatidylinositol 3-kinase-Akt pathway in the normoalbuminuric stage of diabetes mellitus. | 29187367 |
| 2018-06-16 11:59:00 | Data suggest that, in acute kidney injury (here, due to cadmium poisoning), kidney exhibits down-regulation of megalin receptor activity; up-regulation of NFkappaB, TLR2 (toll like receptor-2), and TLR4 (toll like receptor-4); and significant reduction in GSH (glutathione). | 29286200 |
| 2017-08-19 10:13:00 | Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules. | 28289043 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
LRP2_RAT
UniprotKB:
P98158
UniParc:
UPI000013C4B4
EMBL:
L34049
KO:
rno:29216
|
| Nucleutide sequences |
EMBL-CDS:
AAA51369.1
|
| Protein sequencees |
RefSeq:
NP_110454.2
|
| Others |
UniRef100:
UniRef100_P98158
UniRef90:
UniRef90_A2ARV4
UniRef50:
UniRef50_A2ARV4
UniGene:
Rn.26430
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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