| Type | Description |
|---|---|
| Definition | calpain 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-28 11:34:00 | We found that the number of spontaneous seizures detected prior to sample collection was correlated with altered calpain activity and expression | 30423475 |
| 2019-04-06 10:42:00 | The calcium-activated neutral protease-2 (calpain-2) was a direct target gene of miR-137-3p with miR-137-3p binding to the 3'-untranslated region of calpain-2. Silencing of calpain-2 suppressed the expression of neuronal nitric oxide synthase (nNOS), a primary source of nitric oxide (NO). | 29413901 |
| 2019-02-23 13:42:00 | Within 24h following L5 ventral root transection (L5-VRT) model injury observed robust elevation of CALP2 and TNF-alpha in bilateral dorsal root ganglias (DRGs) and bilateral spinal cord neurons. CALP2 and TNF-alpha protein induction by L5-VRT were significantly inhibited by pretreatment using the calpain inhibitor MDL28170. | 29477696 |
| 2019-02-23 12:18:00 | Results implicate calpain-2 in the Ca2+-dependent regulation of extrasynaptic NMDARs and calpain-1 in the Ca2+-dependent regulation of synaptic NMDARs in substantia nigra pars compacta-dopaminergic neurons during the first postnatal week and suggest that these roles of calpain-1 and calpain-2 are developmentally regulated. | 29772491 |
| 2017-10-28 11:00:00 | Results indicate that calpain-1 and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 and CA3, and triggers neurodegenerative cascades. | 27622212 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CAN2_RAT
UniprotKB:
Q07009
UniParc:
UPI0000039F0F
EMBL:
BC065306,
L09120
Ensembl:
ENSRNOG00000034015
KO:
rno:29154
|
| Nucleutide sequences |
EMBL-CDS:
AAH65306.1,
AAA16327.1
Ensembl_TRS:
ENSRNOT00000045326
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000046509
RefSeq:
NP_058812.1
|
| Others |
UniRef100:
UniRef100_Q07009
UniRef90:
UniRef90_Q07009
UniRef50:
UniRef50_Q07009
UniGene:
Rn.6822
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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