| Type | Description |
|---|---|
| Definition | glutamate ionotropic receptor NMDA type subunit associated protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 10:57:00 | PLEC encodes plectin, a cytoskeletal protein that maintains tissue integrity. GRINA encodes TMBIM3, which regulates cell survival. We hypothesized that in a joint predisposed to Osteoarthritis (OA), expression of these genes alters to combat aberrant biomechanics and is epigenetically regulated. However, carriage of the OA risk-conferring allele at this locus hinders this response and contributes to disease development. | 30730609 |
| 2020-01-18 11:11:00 | The cytoplasmic N-terminal half of GRINA (which spans a Proline-rich domain) contains a potential DNA-binding sequence, in addition to cleavage target sites and probable PY-nuclear localization sequences, that may enable it to be released from the rest of the protein and enter the nucleus under suitable conditions, where it could participate in the transcription, alternative splicing, and mRNA export. [review] | 31426446 |
| 2019-02-23 11:32:00 | Human gastric cancers have increased levels of GRINA, which promotes growth of gastric cancer and inhibits tumor cells apoptosis. | 30541591 |
| 2017-01-14 11:57:00 | Extraintestinal manifestations of celiac disease are explained on the basis of 33-mer gliadin binding to glutamate receptor GRINA. | 26990286 |
| 2015-10-03 11:37:00 | These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues | 25764978 |
| Type | IDs |
|---|---|
| Synonymous | HNRGW, LFG1, NMDARA1, TMBIM3 |
| Gene |
UniProtKB-ID:
LFG1_HUMAN
UniprotKB:
Q7Z429
UniParc:
UPI000015A99B
EMBL:
AK127640,
AB097026,
BC084553,
U44954,
BC041788,
CH471416
Ensembl:
ENSG00000178719
KO:
hsa:2907
|
| Nucleutide sequences |
EMBL-CDS:
AAH84553.1,
BAC77379.1,
EAW52305.1,
AAH41788.2,
AAB94292.1,
BAG54539.1
Ensembl_TRS:
ENST00000395068,
ENST00000313269
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000314380,
ENSP00000378507
RefSeq:
NP_000828.1,
NP_001009184.1
|
| Others |
UniRef100:
UniRef100_Q7Z429
UniRef90:
UniRef90_Q7Z429
UniRef50:
UniRef50_Q7Z429
UniGene:
Hs.594634
CCDS:
CCDS34961.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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