ZCCHC4 - zinc finger CCHC-type containing 4-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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29063 ZCCHC4

基因描述

Type	Description
Definition	zinc finger CCHC-type containing 4

研究结论

Date	Results	Publications
2020-03-21 10:35:00	In summary, we establish ZCCHC4 as the enzyme responsible for m6A modification of human 28S rRNA, and demonstrate its functional significance in mRNA translation.	31799605
2020-03-07 10:32:00	3.1 A-resolution crystal structure of human CCHC zinc finger-containing protein ZCCHC4, a 28S rRNA-specific m(6)A methyltransferase, bound to S-adenosyl-L-homocysteine. Mutational and enzymatic analyses further substantiate the molecular basis for ZCCHC4-RNA recognition and a role of the stem-loop structure within substrate in governing the substrate specificity.	31695039
2019-05-11 10:56:00	ZCCHC4 protein is overexpressed in hepatocellular carcinoma tumors.ZCCHC4 is an m6A RNA methyltransferase.	30531910

名称对应

Type	IDs
Synonymous	HSPC052, ZGRF4
Gene	UniProtKB-ID: ZCHC4_HUMAN UniprotKB: Q9H5U6 UniParc: UPI000258D156, UPI0000251F28, UPI000013E833 EMBL: AY629351, AK299211, AK026677, CH471069, BC171821, BC157834, BC016914 Ensembl: ENSG00000168228 KO: hsa:29063
Nucleutide sequences	EMBL-CDS: AAV41218.1, AAI57835.1, EAW92837.1, BAG61250.1, AAI71821.1, BAB15524.1, AAH16914.1 Ensembl_TRS: ENST00000302874, ENST00000507760
Protein sequencees	Ensembl_PRO: ENSP00000303468, ENSP00000422115 RefSeq: XP_011512137.1, XP_016863617.1, XP_016863618.1, NP_079212.2, NP_001305077.1
Others	UniRef100: UniRef100_Q9H5U6 UniRef90: UniRef90_Q9H5U6 UniRef50: UniRef50_Q9H5U6 UniGene: Hs.278945 CCDS: CCDS43218.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
31799605	The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. Nucleic Acids Res. Rita Pinto , Cathrine B VÃ¥gbÃ¸ , Magnus E Jakobsson , Yeji Kim , Marijke P Baltissen , Marie-FranÃ§oise O'Donohue , Ulises H GuzmÃ¡n , JÄdrzej M MaÅecki , Jie Wu , Finn Kirpekar , Jesper V Olsen , Pierre-Emmanuel Gleizes , Michiel Vermeulen , Sebastian A Leidel , Geir Slupphaug , PÃ¥l Ã Falnes	2020-01-24	-
31695039	Structure and regulation of ZCCHC4 in m⁶A-methylation of 28S rRNA. Nat Commun Wendan Ren , Jiuwei Lu , Mengjiang Huang , Linfeng Gao , Dongxu Li , Gang Greg Wang , Jikui Song	2019-11-06	-
31328227	The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. Nhan van Tran , Felix G M Ernst , Ben R Hawley , Christiane Zorbas , Nathalie Ulryck , Philipp Hackert , Katherine E Bohnsack , Markus T Bohnsack , Samie R Jaffrey , Marc Graille , Denis L J Lafontaine	2019-09-05	-
30531910	N^6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat. Chem. Biol. Honghui Ma , Xiaoyun Wang , Jiabin Cai , Qing Dai , S Kundhavai Natchiar , Ruitu Lv , Kai Chen , Zhike Lu , Hao Chen , Yujiang Geno Shi , Fei Lan , Jia Fan , Bruno P Klaholz , Tao Pan , Yang Shi , Chuan He	2019-01-01	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
30209976	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. Cell Cycle Jaewoo Choi , Anita Saraf , Laurence Florens , Michael P Washburn , Luca Busino	2018-01-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell Jesper V Olsen , Blagoy Blagoev , Florian Gnad , Boris Macek , Chanchal Kumar , Peter Mortensen , Matthias Mann	2006-11-03	NR2E3, ABI1, TANK, LINC00322, CHAF1A, TOM1, DNAJB6, SCAMP3, HUWE1, TSSC4, COL4A3BP, RAD50, KIF20A, PDIA6, OPTN, RBM12, YAF2, G3BP1, ADGRG2, CEBPZ, PLXNC1, TRIM28, WASF2, SORBS3, RBM6, RBM5, CDK3, TNK2, MPHOSPH10, MPHOSPH6, TOPORS, SRRM1, STAM2, ABCC4, AKAP8, STUB1, UBE4B, BET1, SF3A1, DNAJA2, PAK4, KATNB1, ZNF267, RTN3, ADAR, TRDN, NPM3, TUBB4B, NDRG1, BASP1, YAP1, CD2BP2, PGRMC2, SEC24B, RBM14, MCRS1, CLGN, LRRC41, NCOA2, SEMA4D, SEMA4B, MYBBP1A, NOP56, ANP32B, RPP30, ARFGEF2, ARFGEF1, CENPA, DNPH1, CENPC, CDC42EP3, PDLIM5, TRIM3, CENPE, CENPF, GAS2L1, IGF2BP1, KHDRBS3, KHDRBS1, CTCF, CETN2, USP39, POLD3, CFL1, NUDC, PTGES3, CFL2, STAG2, RAI1, KIF1C, NUP50, NES, SRSF10, WDR4, SEPT9, HSPH1, UTP14A, FAXDC2, PPP1R13L
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7
15225602	Novel Sm-like proteins with long C-terminal tails and associated methyltransferases. FEBS Lett. Mario Albrecht , Thomas Lengauer	2004-07-02	SCD6, LSM12, LSM12, LSM14B, LSM14A, ZCCHC4, EDC3

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