| Type | Description |
|---|---|
| Definition | nicastrin |
| Date | Results | Publications |
|---|---|---|
| 2017-12-23 11:50:00 | These results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1. | 29176823 |
| 2012-03-03 11:15:00 | Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. | 22086926 |
| 2010-01-21 00:00:00 | At the cellular level, nicastrin is localized predominantly in neuronal cell bodies at early postnatal stages, but is apparent both in cell bodies and dendrites/neuropil in all brain regions at the later stages. | 17222950 |
| 2010-01-21 00:00:00 | The amount of presenilin-1 in the nucleus and membrane fraction was more abundantly expressed in the denervated muscle fibers. In contrast, no significant difference in the nicastrin protein level was observed between normal and denervated muscle fibers. | 16595164 |
| 2010-01-21 00:00:00 | a novel skipped isoform of nicastrin which may suggest a new possible control mechanism based on the alternative splicing and nonsense-mediated mRNA decay to regulate brain protein expression. | 15893582 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
NICA_RAT,
B3DM90_RAT
UniprotKB:
Q8CGU6,
B3DM90
UniParc:
UPI0000251A6E,
UPI00000E8E1B,
UPI00000E8E46
EMBL:
AY101378,
AABR07021769,
CH473985,
BC167747,
AF510722,
AABR07021770
Ensembl:
ENSRNOG00000005355
KO:
rno:289231
|
| Nucleutide sequences |
EMBL-CDS:
AAO15915.1,
AAM44078.1,
EDL94676.1,
AAI67747.1
Gene_ORFName:
rCG_20460
Ensembl_TRS:
ENSRNOT00000008150,
ENSRNOT00000081534
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000008150,
ENSRNOP00000075174
RefSeq:
XP_008767955.1,
NP_777353.1,
XP_008767956.1,
XP_006250345.1,
XP_008767957.1
|
| Others |
UniRef100:
UniRef100_Q8CGU6
UniRef90:
UniRef90_P57716
UniRef50:
UniRef50_Q92542
UniGene:
Rn.51975
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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