| Type | Description |
|---|---|
| Definition | glutamate ionotropic receptor AMPA type subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 11:32:00 | Nanoscale mobility of resting AMPA receptors predetermines responsiveness to neurotransmitter, allosteric anions and auxiliary subunits. Mobility at rest is regulated by alternative splicing of the flip/flop cassette of the ligand-binding domain, which controls motions in the distant AMPA receptor N-terminal domain (NTD). | 31053408 |
| 2020-03-07 10:53:00 | he current study investigated novel curcumin derivatives on the biophysical properties of AMPA receptors, specifically on the homomeric GluA2 and the heteromeric GluA2/A3 subunits and assessed for inhibitory actions | 31454362 |
| 2019-10-26 11:22:00 | Study reports heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability and neurodevelopmental abnormalities. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. | 31300657 |
| 2019-03-23 12:41:00 | Reduced expression of Gria2 increased Ca(2+) influx through Ca(2+)-permeable AMPA receptors which increased the vulnerability and affected the differentiation and migration of distinct cell populations and interfered with normal circuit formation in fragile X syndrome. | 29339535 |
| 2019-03-02 12:09:00 | a dramatic reduction of expression of the GluA2 subunit occurs concomitantly with its hyper-phosphorylation on Serine 880 and increased ubiquitination. Consequently, Cdkl5 silencing skews the composition of membrane-inserted AMPA-Rs towards the GluA2-lacking calcium-permeable form | 29618004 |
| Type | IDs |
|---|---|
| Synonymous | GLUR2, GLURB, GluA2, GluR-K2, HBGR2 |
| Gene |
UniProtKB-ID:
GRIA2_HUMAN
UniprotKB:
P42262
UniParc:
UPI000002AA8D,
UPI00015E0F93,
UPI0000DC90B2,
UPI000012B7C2
EMBL:
AC079233,
BC010574,
AC112240,
BC028736,
L20814
Ensembl:
ENSG00000120251
KO:
hsa:2891
|
| Nucleutide sequences |
EMBL-CDS:
AAA58631.1,
AAH28736.2,
AAH10574.1
Ensembl_TRS:
ENST00000645636,
ENST00000393815,
ENST00000264426,
ENST00000507898,
ENST00000296526
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264426,
ENSP00000495569,
ENSP00000426845,
ENSP00000377403,
ENSP00000296526
RefSeq:
NP_001365929.3,
NP_000817.5,
NP_001077089.2,
NP_001365930.3,
NP_001077088.2
|
| Others |
UniRef100:
UniRef100_P42262
UniRef90:
UniRef90_P19491-2
UniRef50:
UniRef50_P19491
UniGene:
Hs.32763
CCDS:
CCDS3797.1,
CCDS43275.1,
CCDS43274.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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