| Type | Description |
|---|---|
| Definition | growth factor receptor bound protein 14 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:17:00 | These findings suggested that phosphate groups on Ser(358) and Ser(362) in hGrb14 are dephosphorylated by PP1, and the dephosphorylation facilitates hGrb14-IR complex formation. | 31347216 |
| 2018-01-27 11:14:00 | We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. | 27281273 |
| 2017-09-30 11:53:00 | The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor complex formation through phosphorylation, in addition to other domains. | 28130417 |
| 2017-08-12 11:40:00 | Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7) | 28295264 |
| 2017-01-28 10:18:00 | Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis. | 26965150 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GRB14_HUMAN
UniprotKB:
Q14449
UniParc:
UPI000013D489,
UPI0000421DB2
EMBL:
BC053559,
AK301961,
CH471058,
AC110086,
L76687,
AC107075
Ensembl:
ENSG00000115290
KO:
hsa:2888
|
| Nucleutide sequences |
EMBL-CDS:
AAC15861.1,
BAH13595.1,
EAX11342.1,
AAH53559.1
Ensembl_TRS:
ENST00000263915
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263915
RefSeq:
XP_024308584.1,
XP_016859388.1,
NP_004481.2,
XP_011509324.1,
NP_001290351.1,
XP_024308583.1
|
| Others |
UniRef100:
UniRef100_Q14449
UniRef90:
UniRef90_Q14449
UniRef50:
UniRef50_Q14449
UniGene:
Hs.411881
CCDS:
CCDS2222.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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