| Type | Description |
|---|---|
| Definition | beta-secretase 2 |
| Date | Results | Publications |
|---|---|---|
| 2015-05-02 12:57:00 | found by global gene expression profiling that BACE2 was up-regulated in the rat pancreatic beta-cell line INS1E stably transfected with human IAPP gene | 25342134 |
| 2011-06-04 10:51:00 | Data show that astrocytes possess beta-secretase activity and produce amyloid-beta because of the activity of BACE2, but not BACE1, the expression of which is blocked at the translational level. | 21073551 |
| 2010-01-21 00:00:00 | Results describe the functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. | 16757811 |
| 2010-01-21 00:00:00 | The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis. | 19117266 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
BACE2_RAT
UniprotKB:
Q6IE75
UniParc:
UPI00003B3255
EMBL:
BN000318,
BC166597
Ensembl:
ENSRNOG00000001953
KO:
rno:288227
|
| Nucleutide sequences |
EMBL-CDS:
AAI66597.1,
CAE48373.1
Ensembl_TRS:
ENSRNOT00000002679
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000002679
RefSeq:
NP_001002802.1
|
| Others |
UniRef100:
UniRef100_Q6IE75
UniRef90:
UniRef90_Q9JL18
UniRef50:
UniRef50_Q9Y5Z0
UniGene:
Rn.38581
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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