| Type | Description |
|---|---|
| Definition | WNK lysine deficient protein kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2014-10-11 12:49:00 | in addition to and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation. | 24811174 |
| 2011-09-24 11:56:00 | results define a previously undescribed function of WNK4 and reveal a unique therapeutic target to control blood pressure in WNK4-related hypertension | 21670282 |
| 2011-07-09 10:49:00 | salt loading suppressed renal WNK4 expression, activated the Na(+)-Cl(-) cotransporter and induced salt-dependent hypertension | 21499270 |
| 2010-01-21 00:00:00 | WNK4 has a key role in coordinating the activities of diverse flux pathways to achieve integrated fluid and electrolyte homeostasis | 17360470 |
| 2010-01-21 00:00:00 | WNK1 and WNK4 exhibit additive CFTR inhibition. FHHt-causing mutant WNK4 Q562E is a more potent inhibitor of CFTR activity than is the wild-type WNK4. | 17194447 |
| Type | IDs |
|---|---|
| Synonymous | Ac2-059, Prkwnk4 |
| Gene |
UniProtKB-ID:
WNK4_RAT
UniprotKB:
Q7TPK6
UniParc:
UPI000017D859
EMBL:
AY192567,
AY187039
Ensembl:
ENSRNOG00000020441
KO:
rno:287715
|
| Nucleutide sequences |
EMBL-CDS:
AAO18238.1,
AAO38858.1
Ensembl_TRS:
ENSRNOT00000027770
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000027770
RefSeq:
XP_006247341.1,
NP_783169.2,
XP_006247343.1,
XP_006247340.1,
XP_006247342.1
|
| Others |
UniRef100:
UniRef100_Q7TPK6
UniRef90:
UniRef90_Q80UE6
UniRef50:
UniRef50_Q96J92
UniGene:
Rn.228251
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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