Ppm1d - protein phosphatase, Mg2+/Mn2+ dependent, 1D-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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287585 Ppm1d

基因描述

Type	Description
Definition	protein phosphatase, Mg2+/Mn2+ dependent, 1D

研究结论

Date	Results	Publications
2018-07-28 10:11:00	Double immunofluorescence showed colocalization of Wip1 with NF-kappaB in LPS-stimulated primary astrocytes, which indicating a potential interaction between Wip1 with NF-kappaB signaling.	28780681
2017-04-29 12:50:00	Wip1 might participate in astrocyte activation in optic nerve (ON) injury-induced retinal neuroinflammation via regulating NF-kappaB signaling, which may be closely associated with ON injury	27207279
2015-06-20 11:27:00	Suggest that downregulated Wip1 expression plays an important role in Mn-induced neuronal death in the brain striatum via the modulation of p53 signaling.	25791630

名称对应

Type	IDs
Synonymous	Wip1
Gene	UniProtKB-ID: B1WCA0_RAT UniprotKB: B1WCA0 UniParc: UPI0000180D24 EMBL: AABR07030168, BC162058, AABR07030169, CH473948 Ensembl: ENSRNOG00000003329 KO: rno:287585
Nucleutide sequences	EMBL-CDS: AAI62058.1, EDM05544.1 Gene_ORFName: rCG_33706 Ensembl_TRS: ENSRNOT00000004540
Protein sequencees	Ensembl_PRO: ENSRNOP00000004540 RefSeq: NP_001099295.2
Others	UniRef100: UniRef100_B1WCA0 UniRef90: UniRef90_Q9QZ67 UniRef50: UniRef50_O15297 UniGene: Rn.15540

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28780681	Interaction of Wip1 and NF-ÎºB regulates neuroinflammatory response in astrocytes. Inflamm. Res. Fan Xu , Lifei Chen , Xin Zhao , Haibin Zhong , Ling Cui , Li Jiang , Hui Huang , Li Li , Siming Zeng , Min Li	2017-11-01	-
28343630	De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome. Am. J. Hum. Genet. Sandra Jansen , Sinje Geuer , Rolph Pfundt , Rachel Brough , Priyanka Ghongane , Johanna C Herkert , Elysa J Marco , Marjolein H Willemsen , Tjitske Kleefstra , Mark Hannibal , Joseph T Shieh , Sally Ann Lynch , Frances Flinter , David R FitzPatrick , Alice Gardham , Birgitta Bernhard , Nicola Ragge , Ruth Newbury-Ecob , Raphael Bernier , Malin Kvarnung , E A Helena Magnusson , Marja W Wessels , Marjon A van Slegtenhorst , Kristin G Monaghan , Petra de Vries , Joris A Veltman , Deciphering Developmental Disorders Study , Christopher J Lord , Lisenka E L M Vissers , Bert B A de Vries	2017-04-06	-
27207279	Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-ÎºB signaling pathway. Inflamm. Res. Haibin Zhong , Ling Cui , Fan Xu , Lifei Chen , Li Jiang , Hui Huang , Jiping Xu , Xin Zhao , Li Li , Siming Zeng , Min Li	2016-09-01	-
25791630	Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis. Toxicol. Lett. Xia Ma , Jingling Han , Qiyun Wu , Hanzhang Liu , Shangshi Shi , Cheng Wang , Yueran Wang , Jing Xiao , Jianya Zhao , Junkang Jiang , Chunhua Wan	2015-05-19	Tp53, Ppm1d
24135283	Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation. Cancer Cell Doria Filipponi , Julius Muller , Alexander Emelyanov , Dmitry V Bulavin	2013-10-14	-
24002223	Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat. Rev. Mol. Cell Biol. Stephanie Panier , Daniel Durocher	2013-10-01	Vcp, Ubr5, Ppp6c, Ppp4c, Ppp2ca, Ppm1d, Usp16, Rnf4, Otub1, Pias1, Mdc1, Psmd14, L3mbtl1, Eya3, Kdm4a, Usp44, Trip12, Brcc3, Pias4, Usp3, Baz1b, H2afx, Eya1
23242139	Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature Elise Ruark , Katie Snape , Peter Humburg , Chey Loveday , Ilirjana Bajrami , Rachel Brough , Daniel Nava Rodrigues , Anthony Renwick , Sheila Seal , Emma Ramsay , Silvana Del Vecchio Duarte , Manuel A Rivas , Margaret Warren-Perry , Anna Zachariou , Adriana Campion-Flora , Sandra Hanks , Anne Murray , Naser Ansari Pour , Jenny Douglas , Lorna Gregory , Andrew Rimmer , Neil M Walker , Tsun-Po Yang , Julian W Adlard , Julian Barwell , Jonathan Berg , Angela F Brady , Carole Brewer , Glen Brice , Cyril Chapman , Jackie Cook , Rosemarie Davidson , Alan Donaldson , Fiona Douglas , Diana Eccles , D Gareth Evans , Lynn Greenhalgh , Alex Henderson , Louise Izatt , Ajith Kumar , Fiona Lalloo , Zosia Miedzybrodzka , Patrick J Morrison , Joan Paterson , Mary Porteous , Mark T Rogers , Susan Shanley , Lisa Walker , Martin Gore , Richard Houlston , Matthew A Brown , Mark J Caufield , Panagiotis Deloukas , Mark I McCarthy , John A Todd , Breast and Ovarian Cancer Susceptibility Collaboration , Wellcome Trust Case Control Consortium , Clare Turnbull , Jorge S Reis-Filho , Alan Ashworth , Antonis C Antoniou , Christopher J Lord , Peter Donnelly , Nazneen Rahman	2013-01-17	-
23520533	Global identification of genes related to nutrient deficiency in intervertebral disc cells in an experimental nutrient deprivation model. PLoS ONE Hideki Sudo , Katsuhisa Yamada , Koji Iwasaki , Hideaki Higashi , Manabu Ito , Akio Minami , Norimasa Iwasaki	2013-01-01	Ppm1d
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21533982	ATM protein kinase: the linchpin of cellular defenses to stress. Cell Mol Life Sci Shahzad Bhatti , Sergei Kozlov , Ammad Ahmad Farooqi , Ali Naqi , Martin Lavin , Kum Kum Khanna	2011-09-01	-

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