| Type | Description |
|---|---|
| Definition | STIP1 homology and U-box containing protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:21:00 | CHIP attenuates LPS-induced cardiac hypertrophy. | 30980393 |
| 2019-10-26 12:08:00 | In forebrain neuron cultures, C terminus of HSC70-Interacting Protein (CHIP) is critical for neuronal responses to stress. CHIP upregulation and localization to mitochondria is required for mitochondrial autophagy (mitophagy). | 29934347 |
| 2019-01-19 10:49:00 | Study using two rodent models demonstrated that T246M mutation (described in autosomal recessive spinocerebellar ataxia-16 patients) results in structural disorganization and misfolding of the CHIP U-box domain, promoting oligomerization, and increased proteasome-dependent turnover. CHIP-T246M has no ligase activity but maintains interactions with chaperones and chaperone-related functions. | 30222779 |
| 2017-12-16 12:31:00 | upon CHIP knockdown, the expression of Bax and caspase-3 mRNAs increased even further, and the expression of Bcl-2 mRNA was further suppressed. The expression of the phosphorylated p65 and p38 proteins (p-p65 and p-p38) was also further enhanced. Thus, CHIP is a potent cardioprotective molecule. | 28257878 |
| 2017-09-02 10:16:00 | The carboxyl terminus of Hsc70-interacting protein (CHIP) overexpression leads to inhibition of tendon-derived stem cells (TDSCs) differentiation into osteogenic and adipogenic lineages. | 28338815 |
| Type | IDs |
|---|---|
| Synonymous | Chip |
| Gene |
UniProtKB-ID:
D4A4T0_RAT
UniprotKB:
D4A4T0
UniParc:
UPI00001810F2
EMBL:
AABR07029217,
CH473948
Ensembl:
ENSRNOG00000019798
KO:
rno:287155
|
| Nucleutide sequences |
EMBL-CDS:
EDM03968.1
Gene_ORFName:
rCG_34526
Ensembl_TRS:
ENSRNOT00000026921
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000026921
RefSeq:
NP_001020796.2
|
| Others |
UniRef100:
UniRef100_D4A4T0
UniRef90:
UniRef90_Q9WUD1
UniRef50:
UniRef50_Q9WUD1
UniGene:
Rn.6504
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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