| Type | Description |
|---|---|
| Definition | G protein-coupled receptor kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-05 13:52:00 | Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells. | 31349021 |
| 2018-01-20 11:18:00 | GRK4 gene variants in humans (GRK4 A>65L, A>142V, and A>486V) are associated with Hypertension in several but not all ethnic groups. GRK4 gene variants impair the function of D1R and D3R and abet the function of AT1R. These lead to enhancement of renal sodium reabsorption and impaired ability to excrete a sodium load that eventually leads to hypertension. Acknowledgments | 27045027 |
| 2017-12-16 12:08:00 | On normal salt diet, renal CuZnSOD and ECSOD proteins were similar but renal MnSOD was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice. | 28189851 |
| 2017-11-11 13:54:00 | A novel function of GRK4 on triggering a p53-independent cellular senescence, which involves an intricate signaling network. | 28912086 |
| 2016-10-01 10:57:00 | the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients. | 25732908 |
| Type | IDs |
|---|---|
| Synonymous | GPRK2L, GPRK4, GRK4a, IT11 |
| Gene |
UniProtKB-ID:
GRK4_HUMAN
UniprotKB:
P32298
UniParc:
UPI000050AA2B,
UPI000042B0BE,
UPI000042B0BF,
UPI000020BAEC
EMBL:
U33054,
U33168,
BC117320,
U33157,
AK223581,
U33160,
U33163,
U33156,
Z68192,
U33161,
U33154,
U33159,
U33055,
X75897,
U33165,
U33167,
L03718,
U33056,
X97880,
U33164,
X98118,
U33153,
X97879,
X97881,
U33158,
U33162,
U33155,
U33166
Ensembl:
ENSG00000125388
KO:
hsa:2868
|
| Nucleutide sequences |
EMBL-CDS:
CAA66468.1,
AAI17321.1,
AAC50406.1,
AAC50410.1,
AAC50412.1,
AAC50408.1,
BAD97301.1,
CAA92341.1,
CAA66802.1,
CAA53506.1,
AAC50407.1,
AAC50409.1,
AAB04045.1,
CAA66470.1,
AAC50411.1,
CAA66469.1
Ensembl_TRS:
ENST00000345167,
ENST00000398052,
ENST00000504933,
ENST00000398051
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000427445,
ENSP00000381128,
ENSP00000264764,
ENSP00000381129
RefSeq:
XP_011511753.1,
XP_016863546.1,
XP_011511749.1,
NP_001004056.1,
NP_001004057.1,
XP_011511756.1,
XP_016863541.1,
XP_006713943.1,
XP_016863545.1,
XP_016863553.1,
XP_011511755.1,
XP_011511757.1,
XP_011511758.1,
XP_011511754.1,
XP_016863555.1,
NP_005298.2,
XP_016863554.1,
NP_001337102.1,
XP_011511752.1,
XP_016863542.1,
XP_011511759.1,
XP_011511751.1,
NP_892027.2,
XP_016863551.1,
XP_016863552.1,
XP_011511750.1,
XP_016863543.1,
XP_024309783.1,
XP_016863547.1,
XP_016863544.1,
XP_005248019.1,
XP_016863548.1
|
| Others |
UniRef100:
UniRef100_P32298
UniRef90:
UniRef90_P32298
UniRef50:
UniRef50_P32298
UniGene:
Hs.32959
CCDS:
CCDS33947.1,
CCDS33946.1,
CCDS47002.1,
CCDS68656.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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