| Type | Description |
|---|---|
| Definition | PAXX non-homologous end joining factor |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:59:00 | Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination. | 31731258 |
| 2019-07-20 12:17:00 | Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53 | 30579708 |
| 2019-01-19 11:16:00 | PAXX, XLF and XRCC4 synergise in the efficient DNA double-strand breaks recruitment, substrate recognition and stimulation of Pol lambda enzymatic activity during nonhomologous end joining DNA repair. | 30250067 |
| 2018-12-22 11:57:00 | PAXX contributes to base excision repair pathway via interaction of polymerase beta. PAXX deficiency causes TMZ sensitivity. | 30238427 |
| 2017-12-02 11:40:00 | Although PAXX-deficient cells lack c-NHEJ phenotypes, PAXX forms a stable ternary complex with Ku bound to DNA. Thus, PAXX plays an accessory role during c-NHEJ that is largely overlapped by XLF's function. | 27705800 |
| Type | IDs |
|---|---|
| Synonymous | C9orf142, XLS |
| Gene |
UniProtKB-ID:
PAXX_HUMAN
UniprotKB:
Q9BUH6
UniParc:
UPI00014F7AC6,
UPI00001BD908
EMBL:
BC002613,
AL807752,
BC038191
Ensembl:
ENSG00000148362
KO:
hsa:286257
|
| Nucleutide sequences |
EMBL-CDS:
AAH38191.1,
AAH02613.2
Ensembl_TRS:
ENST00000371620
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360682
RefSeq:
NP_001316607.1,
NP_899064.1
|
| Others |
UniRef100:
UniRef100_Q9BUH6
UniRef90:
UniRef90_Q9BUH6
UniRef50:
UniRef50_Q9BUH6
UniGene:
Hs.409582
CCDS:
CCDS7020.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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