| Type | Description |
|---|---|
| Definition | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 11:31:00 | We demonstrate that Topo2a is SUMOylated in an ICRF193-dependent manner by NSE2 at a novel non-canonical site (K1520) and that K1520 sumoylation is required for chromosome segregation but not the G2 arrest. | 30590722 |
| 2019-04-20 12:03:00 | Study the fate of collapsed replication forks generated by prolonged hydroxyurea treatment in NSMCE2-deficient cells. Double strand breaks accumulate during rescue by converging forks in normal cells but not in NSMCE2-deficient cells. Un-rescued forks persist into mitosis, leading to increased mitotic DNA damage. | 30735491 |
| 2017-04-15 10:54:00 | Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand breaks. | 27792189 |
| 2015-05-16 12:26:00 | our study identified novel PVT1-NSMCE2 and CCDC26-NSMCE2 fusion genes that may play functional roles in leukemia. | 25245984 |
| 2015-01-24 11:01:00 | support a role for NSMCE2 in recovery from DNA damage and raise the possibility that loss of its function produces dwarfism through reduced tolerance of replicative stress | 25105364 |
| Type | IDs |
|---|---|
| Synonymous | C8orf36, MMS21, NSE2, ZMIZ7 |
| Gene |
UniProtKB-ID:
NSE2_HUMAN,
A0A024R9J6_HUMAN,
E5RFJ1_HUMAN
UniprotKB:
Q96MF7,
A0A024R9J6,
E5RFJ1
UniParc:
UPI0000424BFA,
UPI0000039EC8
EMBL:
CH471060,
BC032797,
AC084083,
AK057002,
AC126366
Ensembl:
ENSG00000156831
KO:
hsa:286053
|
| Nucleutide sequences |
EMBL-CDS:
AAH32797.1,
BAB71338.1,
EAW92083.1,
EAW92084.1
Gene_ORFName:
hCG_1810826
Ensembl_TRS:
ENST00000522563,
ENST00000287437,
ENST00000517315
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000287437,
ENSP00000430668,
ENSP00000428846
RefSeq:
XP_016868819.1,
XP_016868823.1,
XP_011515277.1,
NP_001336416.1,
XP_016868822.1,
XP_024302898.1,
NP_001336414.1,
XP_016868821.1,
XP_011515276.1,
NP_001336415.1,
NP_775956.1,
XP_016868820.1
|
| Others |
UniRef100:
UniRef100_E5RFJ1,
UniRef100_Q96MF7
UniRef90:
UniRef90_E5RFJ1,
UniRef90_Q96MF7
UniRef50:
UniRef50_M3XQG3,
UniRef50_Q96MF7
UniGene:
Hs.388297
CCDS:
CCDS6356.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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