Type | Description |
---|---|
Definition | ALK and LTK ligand 2 |
Date | Results | Publications |
---|---|---|
2018-07-21 12:08:00 | activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates | 29317532 |
2016-08-27 11:55:00 | In conclusion, these data show that ALK is robustly activated by the FAM150A/B ligands. | 26418745 |
2016-08-20 12:15:00 | Data show FAM150B, which was named as augmentor-alpha (AUG-alpha), binds and activtes both anaplastic lymphoma kinase (ALK) and tyrosine kinase (LTK). | 26630010 |
2015-04-18 11:07:00 | Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation. | 25331893 |
Type | IDs |
---|---|
Synonymous | AUGA, FAM150B, PRO1097, RGPG542 |
Gene |
UniProtKB-ID:
ALKL2_HUMAN,
A0A0B4J1W8_HUMAN
UniprotKB:
Q6UX46,
A0A0B4J1W8
UniParc:
UPI0000037A39,
UPI0000049DFD,
UPI000003ED28
EMBL:
AY358517,
AC079779
Ensembl:
ENSG00000189292
KO:
hsa:285016
|
Nucleutide sequences |
EMBL-CDS:
AAQ88881.1
Gene_ORFName:
UNQ542/PRO1097
Ensembl_TRS:
ENST00000619265,
ENST00000403610,
ENST00000452023
|
Protein sequencees |
Ensembl_PRO:
ENSP00000384604,
ENSP00000478180,
ENSP00000389939
RefSeq:
XP_005264746.1,
XP_006711942.1,
NP_001002919.2,
XP_011508644.1
|
Others |
UniRef100:
UniRef100_Q6UX46
UniRef90:
UniRef90_Q6UX46
UniRef50:
UniRef50_Q6UX46
UniGene:
Hs.355207
CCDS:
CCDS46218.1
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
暂无数据
Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
---|---|---|---|
29317532 |
Proc. Natl. Acad. Sci. U.S.A. Andrey Fadeev , Patricia Mendoza-Garcia , Uwe Irion , Jikui Guan , Kathrin Pfeifer , Stephanie Wiessner , Fabrizio Serluca , Ajeet Pratap Singh , Christiane Nüsslein-Volhard , Ruth H Palmer |
2018-01-23 | - |
26630010 |
Proc. Natl. Acad. Sci. U.S.A. Andrey V Reshetnyak , Phillip B Murray , Xiarong Shi , Elizabeth S Mo , Jyotidarsini Mohanty , Francisco Tome , Hanwen Bai , Murat Gunel , Irit Lax , Joseph Schlessinger |
2016-12-29 | - |
26418745 |
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife Jikui Guan , Ganesh Umapathy , Yasuo Yamazaki , Georg Wolfstetter , Patricia Mendoza , Kathrin Pfeifer , Ateequrrahman Mohammed , Fredrik Hugosson , Hongbing Zhang , Amy W Hsu , Robert Halenbeck , Bengt Hallberg , Ruth H Palmer |
2015-01-01 |
FAM150B,
FAM150A
|
25331893 |
Proc. Natl. Acad. Sci. U.S.A. Hongbing Zhang , Lily I Pao , Aileen Zhou , Arthur D Brace , Robert Halenbeck , Amy W Hsu , Thomas L Bray , Kevin Hestir , Elizabeth Bosch , Ernestine Lee , Gang Wang , Haixia Liu , Brian R Wong , W Michael Kavanaugh , Lewis T Williams |
2014-11-04 |
FAM150B,
FAM150A,
LTK
|
21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
12975309 |
Genome Res. Hilary F Clark , Austin L Gurney , Evangeline Abaya , Kevin Baker , Daryl Baldwin , Jennifer Brush , Jian Chen , Bernard Chow , Clarissa Chui , Craig Crowley , Bridget Currell , Bethanne Deuel , Patrick Dowd , Dan Eaton , Jessica Foster , Christopher Grimaldi , Qimin Gu , Philip E Hass , Sherry Heldens , Arthur Huang , Hok Seon Kim , Laura Klimowski , Yisheng Jin , Stephanie Johnson , James Lee , Lhney Lewis , Dongzhou Liao , Melanie Mark , Edward Robbie , Celina Sanchez , Jill Schoenfeld , Somasekar Seshagiri , Laura Simmons , Jennifer Singh , Victoria Smith , Jeremy Stinson , Alicia Vagts , Richard Vandlen , Colin Watanabe , David Wieand , Kathryn Woods , Ming-Hong Xie , Daniel Yansura , Sothy Yi , Guoying Yu , Jean Yuan , Min Zhang , Zemin Zhang , Audrey Goddard , William I Wood , Paul Godowski , Alane Gray |
2003-10-01 |
Sdhd,
SIGLEC14,
LOC100127951,
LOC100128035,
LOC100128644,
LOC100128816,
LPEQ6126,
QIQN5815,
UNQ6494,
EPWW6493,
LOC100130071,
LOC100130428,
LRRC70,
LOC100130916,
LOC100131131,
CD300LD,
LOC100131541,
LOC100131826,
LOC100131943,
LOC100132099,
LOC100133106,
C17orf99,
INSL5,
PET117,
TOM1,
SH2D3C,
SH2D3A,
LOC100506242,
CASP12,
HCG8,
LOC100507646,
LOC100508226,
FAM24B-CUZD1,
GPC6,
PINK1-AS,
PPIF,
CDH16,
CLEC3A,
DHRS9,
CNIH1,
MPZL2,
ANGPTL7,
LRRC17,
FSTL3,
CWC27,
CNPY2,
B3GNT3,
CCL26,
PRG3,
SPON2,
LRRN2,
GPNMB,
SEMA6B,
SEMA4B,
FBLN5,
LOC105377021,
AGR2,
OLFM4,
COLEC10,
LEFTY1,
TNFSF13B,
CNPY3,
YME1L1,
ARID5A,
HCST,
LYVE1,
DHRS4,
UTS2,
BTNL3,
PRSS21,
SLC27A3,
KLK11,
ADAM30,
ADAMTS13,
CACFD1,
PRSS23,
CLASRP,
FICD,
ERLIN2,
WIF1,
KLK8,
NXPH4,
NXPH3,
MAN1B1,
RDH13,
GLMP,
MGAT4B,
B4GALT7,
CFAP36,
IZUMO4,
CHST14,
CASC4,
VSIG4,
SCRG1,
TEX261,
SIGLEC11,
LACTB,
PGLYRP2,
SLC25A25
|
11181995 |
The sequence of the human genome. Science J C Venter , M D Adams , E W Myers , P W Li , R J Mural , G G Sutton , H O Smith , M Yandell , C A Evans , R A Holt , J D Gocayne , P Amanatides , R M Ballew , D H Huson , J R Wortman , Q Zhang , C D Kodira , X H Zheng , L Chen , M Skupski , G Subramanian , P D Thomas , J Zhang , G L Gabor Miklos , C Nelson , S Broder , A G Clark , J Nadeau , V A McKusick , N Zinder , A J Levine , R J Roberts , M Simon , C Slayman , M Hunkapiller , R Bolanos , A Delcher , I Dew , D Fasulo , M Flanigan , L Florea , A Halpern , S Hannenhalli , S Kravitz , S Levy , C Mobarry , K Reinert , K Remington , J Abu-Threideh , E Beasley , K Biddick , V Bonazzi , R Brandon , M Cargill , I Chandramouliswaran , R Charlab , K Chaturvedi , Z Deng , V Di Francesco , P Dunn , K Eilbeck , C Evangelista , A E Gabrielian , W Gan , W Ge , F Gong , Z Gu , P Guan , T J Heiman , M E Higgins , R R Ji , Z Ke , K A Ketchum , Z Lai , Y Lei , Z Li , J Li , Y Liang , X Lin , F Lu , G V Merkulov , N Milshina , H M Moore , A K Naik , V A Narayan , B Neelam , D Nusskern , D B Rusch , S Salzberg , W Shao , B Shue , J Sun , Z Wang , A Wang , X Wang , J Wang , M Wei , R Wides , C Xiao , C Yan , A Yao , J Ye , M Zhan , W Zhang , H Zhang , Q Zhao , L Zheng , F Zhong , W Zhong , S Zhu , S Zhao , D Gilbert , S Baumhueter , G Spier , C Carter , A Cravchik , T Woodage , F Ali , H An , A Awe , D Baldwin , H Baden , M Barnstead , I Barrow , K Beeson , D Busam , A Carver , A Center , M L Cheng , L Curry , S Danaher , L Davenport , R Desilets , S Dietz , K Dodson , L Doup , S Ferriera , N Garg , A Gluecksmann , B Hart , J Haynes , C Haynes , C Heiner , S Hladun , D Hostin , J Houck , T Howland , C Ibegwam , J Johnson , F Kalush , L Kline , S Koduru , A Love , F Mann , D May , S McCawley , T McIntosh , I McMullen , M Moy , L Moy , B Murphy , K Nelson , C Pfannkoch , E Pratts , V Puri , H Qureshi , M Reardon , R Rodriguez , Y H Rogers , D Romblad , B Ruhfel , R Scott , C Sitter , M Smallwood , E Stewart , R Strong , E Suh , R Thomas , N N Tint , S Tse , C Vech , G Wang , J Wetter , S Williams , M Williams , S Windsor , E Winn-Deen , K Wolfe , J Zaveri , K Zaveri , J F Abril , R Guigó , M J Campbell , K V Sjolander , B Karlak , A Kejariwal , H Mi , B Lazareva , T Hatton , A Narechania , K Diemer , A Muruganujan , N Guo , S Sato , V Bafna , S Istrail , R Lippert , R Schwartz , B Walenz , S Yooseph , D Allen , A Basu , J Baxendale , L Blick , M Caminha , J Carnes-Stine , P Caulk , Y H Chiang , M Coyne , C Dahlke , A Deslattes Mays , M Dombroski , M Donnelly , D Ely , S Esparham , C Fosler , H Gire , S Glanowski , K Glasser , A Glodek , M Gorokhov , K Graham , B Gropman , M Harris , J Heil , S Henderson , J Hoover , D Jennings , C Jordan , J Jordan , J Kasha , L Kagan , C Kraft , A Levitsky , M Lewis , X Liu , J Lopez , D Ma , W Majoros , J McDaniel , S Murphy , M Newman , T Nguyen , N Nguyen , M Nodell , S Pan , J Peck , M Peterson , W Rowe , R Sanders , J Scott , M Simpson , T Smith , A Sprague , T Stockwell , R Turner , E Venter , M Wang , M Wen , D Wu , M Wu , A Xia , A Zandieh , X Zhu |
2001-02-16 | - |
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