| Type | Description |
|---|---|
| Definition | NIMA related kinase 8 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 10:40:00 | NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51. | 27892797 |
| 2016-12-24 11:45:00 | The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 domain of NEK8 in two brothers with cardiac, renal, and hepatic anomalies | 26697755 |
| 2016-08-13 10:54:00 | our study demonstrates that NEK8 human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway | 26967905 |
| 2015-05-09 12:19:00 | NEK8 may be a new target gene of HIFs; pVHL can down-regulate NEK8 via HIFs to maintain the primary cilia structure in human renal cancer cells | 25451921 |
| 2014-01-04 12:24:00 | NEK8 is essential for organ development and that the complete loss of NEK8 perturbs multiple signalling pathways resulting in a severe early embryonic phenotype. | 23418306 |
| Type | IDs |
|---|---|
| Synonymous | JCK, NEK12A, NPHP9, RHPD2 |
| Gene |
UniProtKB-ID:
NEK8_HUMAN
UniprotKB:
Q86SG6
UniParc:
UPI000004B820
EMBL:
BC113705,
AL833909,
CH471159,
AY242354,
AC010761,
AY267371,
BC112240
Ensembl:
ENSG00000160602
KO:
hsa:284086
|
| Nucleutide sequences |
EMBL-CDS:
EAW51136.1,
CAD38765.1,
AAI13706.1,
AAI12241.1,
AAP04006.1,
AAO88243.1
Ensembl_TRS:
ENST00000268766
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000268766
RefSeq:
NP_835464.1
|
| Others |
UniRef100:
UniRef100_Q86SG6
UniRef90:
UniRef90_Q86SG6
UniRef50:
UniRef50_Q86SG6
UniGene:
Hs.448468
CCDS:
CCDS32597.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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