| Type | Description |
|---|---|
| Definition | kinase suppressor of ras 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-20 10:19:00 | These observations suggest that, in the brain, KSR2 regulates energy balance via control of feeding behavior and adaptive thermogenesis, while a second KSR2-dependent mechanism, functioning through one or more other tissues, modulates sensitivity to leptin and activators of the energy sensor AMPK. | 28180061 |
| 2017-11-04 10:49:00 | A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes. | 28537769 |
| 2015-01-24 12:19:00 | KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization. | 24672054 |
| 2014-01-25 10:35:00 | Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells. | 24209692 |
| 2013-08-31 12:04:00 | study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation | 23303246 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
KSR2_HUMAN,
E9PB13_HUMAN
UniprotKB:
Q6VAB6,
E9PB13
UniParc:
UPI000006E3AC,
UPI000164FA1C,
UPI000152636C
EMBL:
AC084291,
BC107106,
AC073864,
BC107107,
AK098831,
AC079127,
AY345972,
AC127166,
BC127603,
AC092936
Ensembl:
ENSG00000171435
KO:
hsa:283455
|
| Nucleutide sequences |
EMBL-CDS:
AAI07108.1,
BAC05426.1,
AAI07107.1,
AAQ24226.1,
AAI27604.1
Ensembl_TRS:
ENST00000339824,
ENST00000425217
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000339952,
ENSP00000389715
RefSeq:
NP_775869.4,
XP_011536527.1,
XP_011536526.1,
XP_011536531.1,
XP_016874699.1,
XP_016874697.1,
XP_011536528.1,
XP_016874698.1
|
| Others |
UniRef100:
UniRef100_Q6VAB6
UniRef90:
UniRef90_Q6VAB6
UniRef50:
UniRef50_Q6VAB6
UniGene:
Hs.375836
CCDS:
CCDS61250.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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