| Type | Description |
|---|---|
| Definition | G protein-coupled receptor 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:02:00 | Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. | 32948783 |
| 2020-03-21 12:30:00 | The expression of GPR4 is upregulated in colorectal cancer and is associated with shorter overall survival time in CRC patients. These findings reveal the novel roles of GPR4 in CRC progression and suggest GPR4 might be a new therapeutic target for CRC treatment. | 31530502 |
| 2019-02-16 10:13:00 | Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4. | 29894771 |
| 2018-04-07 11:59:00 | Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway. | 27256071 |
| 2018-03-10 11:15:00 | These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. | 28270026 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GPR4_HUMAN
UniprotKB:
P46093
UniParc:
UPI0000050428
EMBL:
CH471126,
BC067535,
AC011480,
BC067536,
U35399,
AK290698,
L36148,
EU432116,
U21051
Ensembl:
ENSG00000177464
KO:
hsa:2828
|
| Nucleutide sequences |
EMBL-CDS:
AAA98457.1,
ABY87915.1,
AAA63180.1,
AAH67536.1,
EAW57368.1,
AAH67535.1,
AAA79061.1,
BAF83387.1
Ensembl_TRS:
ENST00000323040
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000319744
RefSeq:
XP_016882097.1,
NP_005273.1,
XP_016882096.1
|
| Others |
UniRef100:
UniRef100_P46093
UniRef90:
UniRef90_P46093
UniRef50:
UniRef50_P46093
UniGene:
Hs.17170
CCDS:
CCDS12669.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员