| Type | Description |
|---|---|
| Definition | G protein-coupled receptor kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-04-29 11:38:00 | The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain. | 27088923 |
| 2013-06-22 10:34:00 | Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK. | 23467820 |
| 2012-04-21 11:30:00 | Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent. | 21826651 |
| 2010-01-21 00:00:00 | G protein-coupled receptor kinase 2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened | 16908539 |
| 2010-01-21 00:00:00 | atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq, Gbetagamma | 16339447 |
| Type | IDs |
|---|---|
| Synonymous | ADRBK1 |
| Gene |
UniProtKB-ID:
ARBK1_BOVIN
UniprotKB:
P21146
UniParc:
UPI0000050ED9
EMBL:
M34019
Ensembl:
ENSBTAG00000005832
KO:
bta:282682
|
| Nucleutide sequences |
EMBL-CDS:
AAA30384.1
Ensembl_TRS:
ENSBTAT00000055962
|
| Protein sequencees |
Ensembl_PRO:
ENSBTAP00000050806
RefSeq:
XP_024842755.1,
NP_777135.1
|
| Others |
UniRef100:
UniRef100_P21146
UniRef90:
UniRef90_P21146
UniRef50:
UniRef50_P26817
UniGene:
Bt.4693
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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