PPP2CA - protein phosphatase 2 catalytic subunit alpha-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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282320 PPP2CA

基因描述

Type	Description
Definition	protein phosphatase 2 catalytic subunit alpha

研究结论

Date	Results	Publications
2016-06-28 10:56:00	changes in PP2A activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function	26569399
2014-12-20 11:02:00	The findings demonstrate an endothelial VEGF resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.	24606881

名称对应

Type	IDs
Gene	UniProtKB-ID: PP2AA_BOVIN UniprotKB: P67774 UniParc: UPI0000000C15 EMBL: M16968, X72858, X52554, BC147979 Ensembl: ENSBTAG00000000469 KO: bta:282320
Nucleutide sequences	EMBL-CDS: AAA30695.1, CAA51381.1, AAI47980.1, CAA36789.1 Ensembl_TRS: ENSBTAT00000000596
Protein sequencees	Ensembl_PRO: ENSBTAP00000000596 RefSeq: NP_851374.1
Others	UniRef100: UniRef100_P67775 UniRef90: UniRef90_P67775 UniRef50: UniRef50_P67775 UniGene: Bt.34380

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
26569399	Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility. PLoS One Tejasvi Dudiki , Suraj Kadunganattil , John K Ferrara , Douglas W Kline , Srinivasan Vijayaraghavan	2015-01-01	-
24606881	Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. Am. J. Pathol. Vishal C Mehra , Elias Jackson , Xian M Zhang , Xian-Cheng Jiang , Lawrence W Dobrucki , Jun Yu , Pascal Bernatchez , Albert J Sinusas , Gerald I Shulman , William C Sessa , Timur O Yarovinsky , Jeffrey R Bender	2014-05-01	Sptlc2, Pycard, VEGFA, PPP2CA
19393038	A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol Aleksey V Zimin , Arthur L Delcher , Liliana Florea , David R Kelley , Michael C Schatz , Daniela Puiu , Finnian Hanrahan , Geo Pertea , Curtis P Van Tassell , Tad S Sonstegard , Guillaume MarÃ§ais , Michael Roberts , Poorani Subramanian , James A Yorke , Steven L Salzberg	2009-01-01	-
16305752	Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics Gregory P Harhay , Tad S Sonstegard , John W Keele , Michael P Heaton , Michael L Clawson , Warren M Snelling , Ralph T Wiedmann , Curt P Van Tassell , Timothy P L Smith	2005-01-01	STK24, UBAP2L, ERCC2, BTNL9, ATRAID, JMJD7, LRWD1, GPSM1, RAD54L, MKS1, CCBL1, FAM161B, LOC107131293, SERPINA1, AK1, AK2, BGN, CEL, CLU, DBH, DCN, DDC, FOS, NPC2, LEP, MOG, OGN, ST7, TST, ZP3, ACTB, PLIN2, AOC3, APOE, ARNT, CGN1, COX4I1, CTSV, ECE1, S1PR1, FDX1, FMOD, FSHR, FUT1, GNB1, GOT1, HPRT1, F11R, LDHB, M6PR, MAOA, MCM3, MDH2, MSRA, NCF1, NT5E, OLR1, P4HB, SERPINE1, PLAU, PLOD1, PON2, PPIB, PSAP, SDHA, SOD2, SPP1, TCN2, TPI1, VIL1, WASL, ACTG2, ALDH1A1, ANXA4, ANXA5, ANXA8L1, BCAT2, BLCAP, C4BPA, CCNB2, CCNG1, ACKR4, DNAJC14, COPZ1, CPSF3, CREB1, CREB3, CTBP2, ECHS1, EDNRA, FABP3, FABP5, HADHB, HSPA2, HSPA8, HYAL2, IKBKB, IKBKG, IMPA1
12578827	Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem Pradipta Ghosh , Stuart Kornfeld	2003-04-18	-
11463346	Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. Biochem. J. J EidenmÃ¼ller , T Fath , T Maas , M Pool , E Sontag , R Brandt	2001-08-01	-
11282978	Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Genome Res. T P Smith , W M Grosse , B A Freking , A J Roberts , R T Stone , E Casas , J E Wray , J White , J Cho , S C Fahrenkrug , G L Bennett , M P Heaton , W W Laegreid , G A Rohrer , C G Chitko-McKown , G Pertea , I Holt , S Karamycheva , F Liang , J Quackenbush , J W Keele	2001-04-01	UBAP2L, ERCC2, BTNL9, SSLP1, C29H11orf68, PHRF1, GTF3A, JMJD7, SETDB1, LRWD1, GPSM1, RAD54L, STON1, C15H11orf96, C5H12orf75, MAP2K5, IFNT3, IFNT, LOC100335806, AOC2, LOC100848357, LOC100848895, SLX4IP, NUS1, MKS1, MEG9, FAM161B, LOC107131293, SERPINA1, AK1, AK2, BGN, CEL, DBH, DDC, FOS, HCK, LEP, MOG, PLG, REN, ST7, ZP3, ACTB, AOC3, ARNT, CGN1, ECE1, ECE2, S1PR1, FSHR, FUT1, GOT1, HPRT1, F11R, MCM3, NCF1, DHRS4, NT5E, OLR1, SERPINE1, PLOD1, PSAP, RCN1, PMEL, TCN2, VIL1, WASL, ABCF1, ANXA4, ANXA8L1, BCAT2, BFSP1, CCNB2, CCNG1, ACKR4, DNAJC14, COPZ1, CPSF3, CREB1, CREB3, EDNRA, TRMT2A, HYAL2, IKBKB, IKBKG, ITPR3, LALBA, MMP14, MOCS1, NCALD, NCAM1, OPCML, OVGP1, POLD2, PPARA, PSMD4, SARS2, TOP2B
11032905	Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. J. Neurochem. M Goedert , S Satumtira , R Jakes , M J Smith , C Kamibayashi , C L White , E Sontag	2000-11-01	-
8396127	Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. J Biol Chem J Lee , J Stock	1993-09-15	-
7681598	Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A. Proc. Natl. Acad. Sci. U.S.A. H Guo , Z Damuni	1993-03-15	-

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