| Type | Description |
|---|---|
| Definition | Terf1 (TRF1)-interacting nuclear factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-23 00:15:00 | The results indicate that TIN2 isoforms are biochemically and functionally distinguishable and that shelterin composition could be fundamentally altered in patients with TINF2 mutations. | 29581185 |
| 2018-08-18 10:13:00 | The TIN2 plays an important role in maintaining the stable shelterin complex required for proper telomere end protection. | 29160297 |
| 2016-07-30 11:54:00 | Gene dosage reductions of Trf1 and/or Tin2 induce telomere DNA damage and lymphoma formation in aging mice. | 26135248 |
| 2015-01-24 11:49:00 | demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes | 25056954 |
| 2014-05-17 10:15:00 | shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1 | 24469404 |
| Type | IDs |
|---|---|
| Synonymous | AW552114, D14Wsu146e, Tin2 |
| Gene |
UniProtKB-ID:
Q8K1K3_MOUSE,
A0A2I3BRL3_MOUSE
UniprotKB:
Q8K1K3,
A0A2I3BRL3
UniParc:
UPI0000D8AE6A,
UPI00000E88EF
EMBL:
BC030347,
CT025679,
AK037673
Ensembl:
ENSMUSG00000007589
KO:
mmu:28113
|
| Nucleutide sequences |
EMBL-CDS:
BAC29848.1,
AAH30347.1
Ensembl_TRS:
ENSMUST00000007733,
ENSMUST00000227842
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000007733,
ENSMUSP00000154628
RefSeq:
XP_006519143.1,
NP_663751.2
|
| Others |
UniRef100:
UniRef100_A0A2I3BRL3,
UniRef100_Q8K1K3
UniRef90:
UniRef90_Q9QXG9
UniRef50:
UniRef50_Q9QXG9
UniGene:
Mm.29346
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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