| Type | Description |
|---|---|
| Definition | NPC intracellular cholesterol transporter 2 |
| Date | Results | Publications |
|---|---|---|
| 2015-10-24 10:05:00 | Data suggest ASM (acid sphingomyelinase) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM may be crucial for endosomal lipid degradation/sorting. | 25339683 |
| 2010-10-23 10:31:00 | Data show that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C. | 20179319 |
| 2010-01-21 00:00:00 | NPC2 plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport. Rates of sterol transfer from and between membranes were increased by as much as 2 orders of magnitude by NPC2. | 18823126 |
| 2010-01-21 00:00:00 | bNPC2 has a loosely packed region penetrating from the surface into the hydrophobic core that forms adjacent small cavities and represents an incipient cholesterol-binding site | 12591954 |
| 2010-01-21 00:00:00 | analysis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease | 17573352 |
| Type | IDs |
|---|---|
| Synonymous | HE1 |
| Gene |
UniProtKB-ID:
NPC2_BOVIN
UniprotKB:
P79345
UniParc:
UPI00001303D9
EMBL:
BC102504,
BT021533,
X85799
Ensembl:
ENSBTAG00000021955
KO:
bta:280815
|
| Nucleutide sequences |
EMBL-CDS:
AAI02505.1,
CAA59794.1,
AAX46380.1
Ensembl_TRS:
ENSBTAT00000029271
|
| Protein sequencees |
Ensembl_PRO:
ENSBTAP00000029271
RefSeq:
XP_005211977.3,
NP_776343.1
|
| Others |
UniRef100:
UniRef100_P79345
UniRef90:
UniRef90_P79345
UniRef50:
UniRef50_Q9Z0J0
UniGene:
Bt.23268
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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