| Type | Description |
|---|---|
| Definition | polo-like kinase 1 (Drosophila) |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 12:50:00 | Targeted inhibition of Plk1 in zebrafish embryos illustrates how centrosomal Plk1 underlies mitotic spindle assembly. Inhibition of kinetochore-associated pools of AurA blocks phosphorylation of microtubule-kinetochore components | 31872801 |
| 2020-01-11 11:01:00 | Studies found that PLK1 asymmetrically localizes between spindle poles under conditions of chromosome misalignment, and chromosomes tend to misalign toward the oldest spindle pole in a cenexin- and PLK1-dependent manner. During chromosome misalignment, PLK1 activity is increased specifically at the oldest spindle pole, and this increase in activity is lost in cenexin-depleted cells. | 31042116 |
| 2013-11-30 11:20:00 | Report the 2.3-A crystal structure of the complex of the N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD together with a PBD-binding motif of Drosophila melanogaster microtubule-associated protein 205 (Map205(PBM)). | 23893132 |
| 2010-09-20 11:19:00 | Studies demonstrate that Plk1 is required for embryonic proliferation because its activity is crucial for mitotic integrity. | 20553902 |
| 2010-01-21 00:00:00 | for the first time that Plk1 can accommodate extended ATP-competitive compounds that project toward the adaptive pocket and help the enzyme order its activation segment | 18678933 |
| Type | IDs |
|---|---|
| Synonymous | cb525, cb636, ik:tdsubc_2d1, plk, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1 |
| Gene |
UniProtKB-ID:
Q4KMI8_DANRE
UniprotKB:
Q4KMI8
UniParc:
UPI000054CA03
EMBL:
HM210100,
BC098545
KO:
dre:280649
|
| Nucleutide sequences |
EMBL-CDS:
ADK12654.1,
AAH98545.1
|
| Protein sequencees |
RefSeq:
NP_001003890.3
|
| Others |
UniRef100:
UniRef100_Q4KMI8
UniRef90:
UniRef90_Q4KMI8
UniRef50:
UniRef50_P70032
UniGene:
Dr.33492
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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