| Type | Description |
|---|---|
| Definition | glutamate dehydrogenase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:26:00 | EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma. | 32034306 |
| 2020-07-25 12:12:00 | our data support the utility of serum GLDH as a liver-specific biomarker of liver injury that has a potential to improve diagnosis of hepatocellular injury in patients with underlying muscle impairments | 32407333 |
| 2020-06-20 10:53:00 | Clinically, XLOC_006390 was positively correlated with the mRNA level of GDH1, and c-Myc positively regulated GDH1 gene expression, which was tightly associated with PC patient prognosis. The dysregulated lncRNA/c-Myc axis increased glutamate metabolism, promoting PC progression to a higher stage. | 31734356 |
| 2020-04-11 10:19:00 | Low expression of GDH can significantly inhibit gastric cancer cell migration, invasion and proliferation, and decrease in the expression levels of Notch1, Notch2, Notch3 and Notch4 in vitro. GDH suppressed tumor growth and metastasis by mediating the Notch signaling pathway in mice with gastric cancer. Therefore, GDH-Notch signaling pathway is considered an important target of anti-tumor growth and metastasis. | 31322543 |
| 2020-03-28 10:32:00 | GluD1 defines a trans-synaptic interaction regulating postsynaptic signaling pathways for the proper establishment of cortical inhibitory connectivity | 31704028 |
| Type | IDs |
|---|---|
| Synonymous | GDH, GDH1, GLUD |
| Gene |
UniProtKB-ID:
DHE3_HUMAN,
E9KL48_HUMAN
UniprotKB:
P00367,
E9KL48
UniParc:
UPI0000EE74BA,
UPI00017A6DB8,
UPI0000001C96
EMBL:
X67491,
X66302,
M37154,
X66300,
X66301,
GQ891382,
X66303,
X07674,
CH471142,
M20867,
X66307,
X66305,
BC112946,
AL136982,
X07769,
AK294685,
X66306,
X66304,
X66311,
AK122685,
BC040132,
X66308,
X66309,
J03248,
GU727646,
X66312
Ensembl:
ENSG00000148672
KO:
hsa:2746
|
| Nucleutide sequences |
EMBL-CDS:
AAH40132.1,
AAA52525.1,
BAG53667.1,
BAG57846.1,
EAW80300.1,
EAW80302.1,
CAA30521.1,
CAA30598.1,
CAI17120.1,
AAA52523.1,
CAA47830.1,
CAA46994.2,
AAI12947.1,
AAA52526.1,
ADO22244.1,
EAW80304.1,
ADU87647.1
Gene_ORFName:
hCG_1993805
Ensembl_TRS:
ENST00000277865
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000277865
RefSeq:
NP_001305829.1,
NP_001305834.1,
NP_001305831.1,
NP_001305835.1,
NP_005262.1,
NP_001305833.1,
NP_001305830.1
|
| Others |
UniRef100:
UniRef100_P00367
UniRef90:
UniRef90_P00367
UniRef50:
UniRef50_P00367
UniGene:
Hs.500409
CCDS:
CCDS7382.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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