| Type | Description |
|---|---|
| Definition | RAB guanine nucleotide exchange factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-09-01 12:06:00 | The authors demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. | 29360040 |
| 2018-07-28 11:40:00 | RABEX-5 mRNA expression was significantly upregulated in colorectal cancer tissues. | 28617553 |
| 2018-01-27 11:42:00 | we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs. | 27601648 |
| 2017-12-09 10:18:00 | RABGEF1 mediates recycling endosome fusion with GAS-containing autophagosome-like vacuoles through the STX6-VAMP3-VTI1B complex; SNAREs are involved in autophagosome formation in response to bacterial infection | 27791468 |
| 2017-09-02 11:04:00 | findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function | 27820702 |
| Type | IDs |
|---|---|
| Synonymous | RABEX5, RAP1, rabex-5 |
| Gene |
UniProtKB-ID:
RABX5_HUMAN,
A8K3R3_HUMAN,
A0A024RDL6_HUMAN,
B3KMF1_HUMAN
UniprotKB:
Q9UJ41,
A8K3R3,
A0A024RDL6,
B3KMF1
UniParc:
UPI00005C932B,
UPI000015F394,
UPI00015DA6F0,
UPI00017A848C,
UPI00000730D5
EMBL:
DQ230533,
BC015330,
DQ230534,
AC027644,
CH471140,
AJ250042,
AK001702,
AK303006,
AK127790,
AK223329,
AC079588,
BT007107,
AK290678
Ensembl:
ENSG00000154710
KO:
hsa:27342
|
| Nucleutide sequences |
EMBL-CDS:
BAD97049.1,
BAC87138.1,
ABA64473.1,
AAQ93362.1,
BAG64139.1,
AAP35771.1,
ABA64474.1,
AAH15330.1,
CAB57359.1,
BAF83367.1,
EAX07916.1,
EAX07914.1,
BAG50963.1
Gene_ORFName:
hCG_39434
Ensembl_TRS:
ENST00000284957,
ENST00000380828,
ENST00000450873
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370208,
ENSP00000415815,
ENSP00000284957
RefSeq:
NP_001354667.1,
NP_001354661.1,
NP_001354682.1,
NP_001354677.1,
NP_001354654.1,
NP_001354673.1,
NP_001354678.1,
NP_001354685.1,
NP_001273989.1,
NP_001273991.1,
NP_001354662.1,
NP_001354658.1,
NP_001354675.1,
NP_001354659.1,
NP_001354660.1,
NP_001354671.1,
NP_001354679.1,
NP_001354664.1,
NP_001354663.1,
NP_001354652.1,
NP_001354665.1,
NP_055319.1,
NP_001354656.1,
NP_001354681.1,
NP_001354651.1,
NP_001354676.1,
NP_001354674.1,
NP_001354657.1,
NP_001354684.1,
NP_001273990.1,
NP_001354653.1,
NP_001354670.1,
NP_001354666.1,
NP_001354669.1,
NP_001354655.1,
NP_001354680.1,
NP_001354683.1,
NP_001354668.1,
NP_001354672.1
|
| Others |
UniRef100:
UniRef100_A8K3R3,
UniRef100_Q9UJ41-3,
UniRef100_Q9UJ41
UniRef90:
UniRef90_Q9UJ41
UniRef50:
UniRef50_Q9UJ41
UniGene:
Hs.530053
CCDS:
CCDS69308.1,
CCDS5535.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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