| Type | Description |
|---|---|
| Definition | glutamate-cysteine ligase catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 10:41:00 | Results provide evidence that the functional SNPs rs17883901 in GCLC and rs713041 in GPX4 modulate the risk for diabetic retinopathy in the studied population of type 1 diabetes individuals, widening the spectrum of candidate genes for this complication. | 30959073 |
| 2018-08-25 10:27:00 | Study found that the frequency of C/T polymorphism genotype of GCLC gene in patients with pulmonary tuberculosis is 36.4%. | 29023060 |
| 2018-07-21 11:24:00 | the present study demonstrated that cells transformed by chronic exposure to 3MC exhibited inhibition of GSH biosynthesis by suppression of GCL protein expression and reduction of cysteine availability, which may subsequently render cells vulnerable to oxidative stress. | 29039508 |
| 2018-07-07 12:04:00 | Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 macrophages is tightly and differentially regulated via GCLC and GCLM subunits of glutamate cysteine ligase. | 28993271 |
| 2018-06-02 10:04:00 | High expression of GCLC in tumor tissue may be a potential predictor of treatment failure. | 29474642 |
| Type | IDs |
|---|---|
| Synonymous | GCL, GCS, GLCL, GLCLC |
| Gene |
UniProtKB-ID:
GSH1_HUMAN,
Q14TF0_HUMAN,
E1CEI4_HUMAN
UniprotKB:
P48506,
Q14TF0,
E1CEI4
UniParc:
UPI0001E556E9,
UPI000000D970
EMBL:
BC039894,
M90656,
AB262176,
AL033397,
AF118846,
AK313480,
AY780794,
AB516284,
L39773,
CH471081,
BC022487
Ensembl:
ENSG00000001084
KO:
hsa:2729
|
| Nucleutide sequences |
EMBL-CDS:
AAD18031.1,
AAC41751.1,
AAV31778.1,
AAH22487.1,
AAA58499.1,
AAH39894.1,
BAE97618.1,
EAX04426.1,
BAG36264.1,
EAX04425.1,
BAJ21361.1
Gene_ORFName:
hCG_21942
Ensembl_TRS:
ENST00000650454,
ENST00000513939
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000497574,
ENSP00000424211
RefSeq:
NP_001489.1,
NP_001184044.1,
XP_016866238.1
|
| Others |
UniRef100:
UniRef100_P48506,
UniRef100_E1CEI4
UniRef90:
UniRef90_P48506
UniRef50:
UniRef50_P48506
UniGene:
Hs.654465
CCDS:
CCDS4952.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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