| Type | Description |
|---|---|
| Definition | kelch like family member 20 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:29:00 | A 1.1-A degrees crystal structure of a KLHL20-DAPK1 complex reveals a hydrophobic pocket in KLHL20. DAPK1 helical turn inserts into the beta-propeller to contact all six Kelch repeats of KLHL20. | 31279627 |
| 2016-05-28 10:06:00 | Study identifies a key role of Cul3-KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism. | 26687681 |
| 2014-07-12 11:49:00 | study reveals a function of KLHL20-mediated, K33-linked ubiquitination of Crn7 in the assembly of (trans-Golgi network )TGN-associated F-actin to promote post-Golgi trafficking and identifies a cellular decoding mechanism for this ubiquitin chain type. | 24768539 |
| 2011-12-10 11:19:00 | These results indicate that KLHL20 is a novel player that regulates HIF-2alpha protein expression through mechanisms independent of hypoxia and pVHL. | 21888897 |
| 2011-10-15 10:53:00 | study indicates that the KLHL20-mediated PML degradation and HIF-1alpha autoregulation play key roles in tumor progression | 21840486 |
| Type | IDs |
|---|---|
| Synonymous | KHLHX, KLEIP, KLHLX |
| Gene |
UniProtKB-ID:
KLH20_HUMAN
UniprotKB:
Q9Y2M5
UniParc:
UPI00017A7F92,
UPI0000227E1A
EMBL:
AJ844466,
AK300755,
BX248409,
AB026190,
AL109921,
AK001430,
BC063418
Ensembl:
ENSG00000076321
KO:
hsa:27252
|
| Nucleutide sequences |
EMBL-CDS:
CAH59617.1,
BAA77027.1,
AAH63418.1,
BAG50912.1,
BAG62422.1
Ensembl_TRS:
ENST00000209884
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000209884
RefSeq:
NP_055273.2,
XP_024302236.1,
XP_016856543.1,
XP_016856541.1,
XP_011507722.1,
XP_024302240.1,
XP_016856542.1,
XP_005245150.1
|
| Others |
UniRef100:
UniRef100_Q9Y2M5
UniRef90:
UniRef90_Q9Y2M5
UniRef50:
UniRef50_Q9Y2M5
UniGene:
Hs.495035
CCDS:
CCDS1310.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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