| Type | Description |
|---|---|
| Definition | sestrin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:11:00 | Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpression suffices to prevent atrophy. This protection occurs through mTORC1 inhibition, which upregulates autophagy, and AKT activation, which in turn inhibits FoxO-regulated ubiquitin-proteasome-mediated proteolysis. Sestrin protects muscles against aging-induced atrophy(sarcopenia). | 31929511 |
| 2019-11-23 11:54:00 | identified new interactions between miR-200 and the oxidative stress response SESN proteins that affect anoikis resistance in human endometrial cancer cells. | 31073887 |
| 2019-06-08 10:42:00 | mRNA expression of SESN1 was upregulated in older men. | 29751091 |
| 2018-07-07 12:11:00 | Study shows that SESN1 mRNA, UHRF1BP11 mRNA and miRNA-377-3p levels are prognostically relevant in human papillomavirus-negative head and neck squamous cell carcinoma patients. | 28886272 |
| 2018-03-31 12:18:00 | The antitumor efficacy of pharmacological EZH2 inhibition depends on SESTRIN1, indicating that mTORC1 control is a critical function of EZH2 in lymphoma. | 28659443 |
| Type | IDs |
|---|---|
| Synonymous | PA26, SEST1 |
| Gene |
UniProtKB-ID:
SESN1_HUMAN
UniprotKB:
Q9Y6P5
UniParc:
UPI000002B36C,
UPI000013588F,
UPI000002B36B
EMBL:
CH471051,
AF033121,
AL390208,
AF033122,
AF033120,
BC112036,
BC113569,
AK001886
Ensembl:
ENSG00000080546
KO:
hsa:27244
|
| Nucleutide sequences |
EMBL-CDS:
EAW48367.1,
AAD04811.1,
AAD04812.1,
AAD04810.1,
AAI12037.1,
EAW48368.1,
BAA91961.1,
AAI13570.1
Ensembl_TRS:
ENST00000436639,
ENST00000356644,
ENST00000302071
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000306734,
ENSP00000349061,
ENSP00000393762
RefSeq:
NP_001186863.1,
NP_055269.1,
NP_001186862.1
|
| Others |
UniRef100:
UniRef100_Q9Y6P5
UniRef90:
UniRef90_Q9Y6P5
UniRef50:
UniRef50_Q9Y6P5
UniGene:
Hs.591336
CCDS:
CCDS56445.1,
CCDS56444.1,
CCDS5070.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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