| Type | Description |
|---|---|
| Definition | Spi-B transcription factor (Spi-1/PU.1 related) |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:42:00 | Opposing Roles for the Related ETS-Family Spi-B and Spi-C in Regulating Differentiation and Function. | 32457757 |
| 2020-11-21 13:33:00 | The mechanism of action of Spi-B in the transcriptional activation of the interferon-alpha4 gene. | 32111355 |
| 2018-09-22 11:27:00 | Mice lacking both PU.1 and SpiB in mature B cells do not generate germinal centers and high-affinity antibody after protein immunization. PU.1 and SpiB double-deficient B cells have a survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhanced plasma cell differentiation. | 29127283 |
| 2017-12-02 12:15:00 | Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity. | 27974197 |
| 2015-12-05 11:10:00 | Our results suggest that complementary biological functions of PU.1 and Spi-B may be explained by their interaction with a similar set of regions in the genome of B cells. | 25765478 |
| Type | IDs |
|---|---|
| Synonymous | Spi-B |
| Gene |
UniProtKB-ID:
SPIB_MOUSE
UniprotKB:
O35906
UniParc:
UPI000052A474,
UPI00001C3C76,
UPI00001E40F0
EMBL:
U87618,
U87620,
U87619,
U87616,
U87614,
U87617
Ensembl:
ENSMUSG00000008193
KO:
mmu:272382
|
| Nucleutide sequences |
EMBL-CDS:
AAC53554.1,
AAC53556.1,
AAC53559.1,
AAC53557.1
Ensembl_TRS:
ENSMUST00000035323
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000035539
RefSeq:
XP_006541001.1,
XP_006541002.1,
XP_030098488.1,
XP_006540999.1,
XP_006540997.1,
XP_006540998.1,
NP_063919.1,
XP_006540995.1,
XP_006540996.1,
XP_030098487.1
|
| Others |
UniRef100:
UniRef100_O35906
UniRef90:
UniRef90_O35906
UniRef50:
UniRef50_Q01892
UniGene:
Mm.8012
CCDS:
CCDS21209.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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