| Type | Description |
|---|---|
| Definition | serum/glucocorticoid regulated kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-16 12:02:00 | VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose. | 28911860 |
| 2010-01-21 00:00:00 | the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development | 15871460 |
| Type | IDs |
|---|---|
| Synonymous | AI098171, AW146006, Sgkl |
| Gene |
UniProtKB-ID:
SGK2_MOUSE,
Q3UW73_MOUSE
UniprotKB:
Q9QZS5,
Q3UW73
UniParc:
UPI00005ABCC9,
UPI000002B386,
UPI0000021565
EMBL:
AK050009,
BC026549,
AF169033,
AK136559,
AL591584
Ensembl:
ENSMUSG00000017868
KO:
mmu:27219
|
| Nucleutide sequences |
EMBL-CDS:
BAC34031.1,
AAF12756.1,
AAH26549.1,
BAE23044.1
Ensembl_TRS:
ENSMUST00000018012,
ENSMUST00000117123
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000018012,
ENSMUSP00000112468
RefSeq:
XP_006499721.1,
NP_038759.1,
XP_011237882.1,
NP_001278083.1,
NP_001278081.1,
XP_006499723.1
|
| Others |
UniRef100:
UniRef100_Q3UW73,
UniRef100_Q9QZS5
UniRef90:
UniRef90_Q9QZS5,
UniRef90_A0A6J2MKY9
UniRef50:
UniRef50_Q9QZS5,
UniRef50_Q06226
UniGene:
Mm.26462
CCDS:
CCDS71184.1,
CCDS17004.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 28911860 |
Cell. Signal. Saki Gotoh , Yuu Miyauchi , Rick Moore , Masahiko Negishi |
2017-12-01 | - |
| 27689697 |
PLoS Genet. Yong Wu , Fan-Yan Wei , Layla Kawarada , Takeo Suzuki , Kimi Araki , Yoshihiro Komohara , Atsushi Fujimura , Taku Kaitsuka , Motohiro Takeya , Yuichi Oike , Tsutomu Suzuki , Kazuhito Tomizawa |
2016-09-01 | - |
| 24703692 |
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. Matthew J Harms , Jeff Ishibashi , Wenshan Wang , Hee-Woong Lim , Susumu Goyama , Tomohiko Sato , Mineo Kurokawa , Kyoung-Jae Won , Patrick Seale |
2014-04-01 |
Mybpc1,
Adipoq,
Agt,
Fabp4,
Casq1,
Cidea,
Cideb,
Elovl3,
Cox5b,
Cox7a1,
Cycs,
Cyp2b10,
Dio2,
Mecom,
Gt(ROSA)26Sor,
Myf5,
Myf6,
Myh8,
Mylpf,
Myod1,
Myog,
Myom2,
Neb,
Nnmt,
Ppara,
Pparg,
Ppargc1a,
Ryr1,
Tpm2,
Ucp1,
Adgrg2,
Sgk2,
Tfr2,
Retn,
Sirt5,
Flnc,
Prdm16,
Trim14,
Ehmt1
|
| 22967998 |
Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Dev. Biol. Tali Shalom-Barak , Xiaowen Zhang , Tianjiao Chu , W Timothy Schaiff , Janardan K Reddy , Jianming Xu , Yoel Sadovsky , Yaacov Barak |
2012-12-01 |
Hrct1,
Kcnj13,
Slc45a4,
Pkdcc,
Egln3,
Hsd17b11,
Aldoc,
Tpbpb,
Rnd2,
Cav1,
Clu,
Cxcr4,
Dgat1,
Sparcl1,
Emp2,
Epas1,
Epha4,
Fn1,
Gcgr,
Gcm1,
Ghrh,
Tsc22d3,
Gjb2,
Gm2a,
Hbegf,
Hpgd,
Hsd11b2,
Igfbp2,
Itk,
Ldhb,
Lepr,
Lifr,
Pdzd3,
Bbc3,
Maoa,
Mertk,
Mitf,
Mmp15,
Muc1,
Nfkb2,
Nid2,
Pcx,
Abcb1b,
Prkce,
Prl3b1,
Plat,
Pparg,
Ppargc1a,
Lgals3bp,
Prlr,
Pstpip1,
Ptger3,
Pthlh,
Rb1,
Scd2,
St8sia2,
Slc22a3,
Smpd1,
C2cd2,
Stc1,
Plekhh2,
Tgfb3,
Rnf144b,
Tpbpa,
Scgb1a1,
Vnn1,
Ywhaz,
Zfp185,
Vash2,
Megf9,
Tmem125,
Ncmap,
Sel1l3,
Eva1a,
Pxylp1,
Als2cl,
Nt5e,
Mab21l3,
Slc13a4,
Tmem255a,
Dcaf12l1,
Tceanc,
Vasn,
Map3k12,
Adck5,
Acot1,
Sgk2,
Nostrin,
L1td1,
Sgpp2,
Dppa5a,
Dkkl1,
Atp2a3,
Prdx4,
Irf6,
Ccrl2,
Rassf5,
St3gal6,
Car5b
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 20926631 |
Am J Physiol Renal Physiol Alan C Pao , Aditi Bhargava , Francesca Di Sole , Raymond Quigley , Xinli Shao , Jian Wang , Sheela Thomas , Jianning Zhang , Mingjun Shi , John W Funder , Orson W Moe , David Pearce |
2010-12-01 | - |
| 16460280 |
Sgk kinases and their role in epithelial transport. Annu. Rev. Physiol. Johannes Loffing , Sandra Y Flores , Olivier Staub |
2006-01-01 |
Sgk3,
Sgk1,
Sgk2,
C8orf44-SGK3,
SGK2,
SGK3,
SGK1
|
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 15871460 |
DNA Res. Kentaro Masujin , Taro Okada , Takehito Tsuji , Yoshiyuki Ishii , Kaoru Takano , Junichiro Matsuda , Atsuo Ogura , Tetsuo Kunieda |
2005-12-31 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员