| Type | Description |
|---|---|
| Definition | sialic acid binding Ig like lectin 8 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:39:00 | Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma. | 32077788 |
| 2020-05-09 10:46:00 | Siglec-8 is highly expressed on blood eosinophils from eosinophilic donors and normal donors and represents a potential therapeutic target for eosinophilic disorders | 30543818 |
| 2019-08-03 13:42:00 | These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases | 28888781 |
| 2019-08-03 11:03:00 | Targeting saporin to Siglec-8 consistently caused extensive cell death. | 28734845 |
| 2017-09-16 11:55:00 | In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2. | 27154355 |
| Type | IDs |
|---|---|
| Synonymous | SAF2, SIGLEC-8, SIGLEC8L |
| Gene |
UniProtKB-ID:
SIGL8_HUMAN
UniprotKB:
Q9NYZ4
UniParc:
UPI000002B3B5,
UPI000013598B,
UPI000002B3B6
EMBL:
BC053319,
AF195092,
AF223403,
AF310234,
AF287892
Ensembl:
ENSG00000105366
KO:
hsa:27181
|
| Nucleutide sequences |
EMBL-CDS:
AAF27622.1,
AAK55140.1,
AAF34702.1,
AAH53319.1,
AAG00573.1
Ensembl_TRS:
ENST00000321424,
ENST00000340550
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000339448,
ENSP00000321077
RefSeq:
NP_001350477.1,
NP_055257.2,
XP_011525036.1
|
| Others |
UniRef100:
UniRef100_Q9NYZ4
UniRef90:
UniRef90_Q9NYZ4
UniRef50:
UniRef50_Q9NYZ4
UniGene:
Hs.447899
CCDS:
CCDS33086.1,
CCDS86797.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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